02270naa a2200301 a 450000100080000000500110000800800410001902400390006010000200009924501380011926000090025750001540026652012420042065000200166265300150168265300190169765300240171665300280174065300200176865300170178865300090180570000230181470000180183770000280185570000200188370000180190377300470192110576212019-11-05       2017    bl uuuu     u00u1 u    #d7 a10.1016/j.toxicon.2017.09.0092DOI1 aARAÚJO, V.O.DE  aPrimary photosensitization and contact dermatitis caused by Malachra fasciata Jacq. N.V. (Malvaceae) in sheep.h[electronic resource]  c2017  aArticle history: Received 20 July 2017.//Received in revised form 11 September 2017.//Accepted 11 September 2017 //Available online 14 September 2017  aAbstract: Farmers from Paraiba state, Northeast Brazil, claim that Malachra fasciata causes cutaneous lesions in sheep. To test its toxicity the plant was harvested daily and fed ad libitum for 21 days to 3 sheep as the sole food source (# 1?3). An additional sheep (# 4) was maintained as a control. Cutaneous lesions of photosensitization initiated after 7 days and increased continuously over the next 21 days. The dose ingested varied between 129 g/kg to 175 g/kg. Alopecia, hyperemia and crusting were observed in the animals. On day 22, sheep 3 was euthanized. At necropsy, no gross or microscopic alterations were observed in the liver. Skin biopsies were performed in the remaining animals Histopathology of skin of the three sheep included acanthosis, orthokeratosis, and multifocal infiltration by lymphocytes, eosinophils and plasma cells around blood vessels and appendages in the dermis. The Splendore-Hoeppli phenomenon was observed in the dermis of sheep 2, due probably by contact dermatitis. After the end of administration Sheep 1 and 2 were protected from sunlight and the lesions regressed within two weeks. This experiment indicates that M. fasciata causes primary photosensitization and contact dermatitis in sheep.  aPLANTAS TOXICAS  aDERMATITIS  aENVENENAMIENTO  aLESIONES DE LA PIEL  aPLATAFORMA SALUD ANIMAL  aPOISONING PLANT  aSALUD ANIMAL  aSKIN1 aOLIVEIRA NETO, T.S1 aSIMOES, S.V.D1 aFERREIRA DA SILVA, T.K.1 aRIET-CORREA, F.1 aLUCENA , R.B.  tToxicon, 2017 Nov, volumen 138, p.184-187.