02886naa a2200277 a 450000100080000000500110000800800410001902200140006002400360007410000170011024501130012726000090024050005330024952015640078265300210234665300090236765300100237665300090238665300130239565300150240870000220242370000150244570000200246070000160248077301120249610642522023-07-13       2023    bl uuuu     u00u1 u    #d  a0034-52887 a10.1016/j.rvsc.2023.06.0012DOI1 aPASSOS, L.T.  aSystematic review of the relationship between rumen acidosis and laminitis in cattle.h[electronic resource]  c2023  aArticle history: Received 29 March 2023; Received in revised form 30 May 2023; Accepted 1 June 2023; Available online 8 June 2023. -- Correspondence author:   Fischer, V.; Department of Animal Science, Federal University of Rio Grande do Sul, Rio Grande do Sul, Porto Alegre, Brazil; email:vivian.fischer@ufrgs.br  -- FUNDING: The authors thank the Brazilian National Research Council - CNPq for the fellow research grants, to the Coordination for the Improvement of Higher Education Personnel (CAPES) for scholarship grants. --  aLaminitis is usually considered a consequence of digestive disorders that reduce ruminal pH. However, it is still not clear the direct relation between low ruminal pH provoked by excessive fast-digesting carbohydrate ingestion and laminitis, considering indicators, signs, and diagnosis aspects. This study aimed to clarify the association between different clinical presentations of laminitis with ruminal acidosis provoked by diet using the systematic review methodology. Three electronic databases were used: ISI Web of Science, PubMed, and Scopus. A total of 339 manuscripts were identified and only 16 were included. Manuscripts were published between 2000 and 2021 in 11 different peer-reviewed journals. Fifteen studies confirmed the occurrence of ruminal acidosis. The main indicators used were ruminal pH and clinical signs, such as anorexia, depression, discomfort and diarrhea. Two of the studies that administered oligofructose to induce acidosis and acute laminitis did not observe clinical signs of laminitis, using lameness score or hooves' sensitivity as an indicator. Various diagnostic methods were used to describe laminitis, like thermography, hoof biopsy, sensitivity test, and visual inspection. Although the variety of laminitis indicators used in the included studies, we evidence the existence of an association between diet (high level of fast-digesting carbohydrates), ruminal acidosis, and acute laminitis, mostly in the short-term acidosis' induction protocols, but the mechanism of action is still not clear. © 2023 Elsevier Ltd  aAnimal nutrition  aBeef  aDairy  aHoof  aLameness  aRuminal pH1 aBETTENCOURT, A.F.1 aRITT, L.A.1 aCANOZZI, M.E.A.1 aFISCHER, V.  tResearch in Veterinary Science. 2023, Volume 161, Pages 110-117. https://doi.org/10.1016/j.rvsc.2023.06.001