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 | Acceso al texto completo restringido a Biblioteca INIA Las Brujas. Por información adicional contacte bibliolb@inia.org.uy. |
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha : |
21/10/2024 |
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Actualizado : |
21/10/2024 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
LOZANO, J.; FABIUS, S.; FERNÁNDEZ-CIGANDA, S.; URBANAVICIUS, J.; PICCINI, C.; SCORZA, C.; ZUNINO, Z. |
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Afiliación : |
J. LOZANO, Department of Microbiology, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay; S. FABIUS, Department of Experimental Neuropharmacology, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay; SOFÍA FERNÁNDEZ-CIGANDA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; Department of Microbiology, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay; J. URBANAVICIUS, Department of Experimental Neuropharmacology, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay; C. PICCINI, Department of Microbiology, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay; C. SCORZA, Department of Experimental Neuropharmacology, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay; P. ZUNINO, Department of Microbiology, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay. |
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Título : |
Beneficial effect of GABA-producing Lactiplantibacillus strain LPB145 isolated from cheese starters evaluated in anxiety- and depression-like
behaviours in rats. |
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Complemento del título : |
Research article. |
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Fecha de publicación : |
2024 |
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Fuente / Imprenta : |
Beneficial Microbes, 2024, Volume 15, Issue 5, Pages 465-479. https://doi.org/10.1163/18762891-bja00024 |
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ISSN : |
1876-2891 (online) |
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DOI : |
10.1163/18762891-bja00024 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received 21 October 2023, Accepted 19 June 2024, Published online 4 July 2024. -- Correspondence: Zunino, P.; Department of Microbiology, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay; email:pmzunino@gmail.com -- Published with license by Koninklijke Brill BV. |
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Contenido : |
ABSTRACT.- In a previous study, we reported the in vitro potential probiotic and gamma-aminobutyric acid (GABA) production, of several strains from a collection of Lactiplantibacillus (Lpb) strains within the community of natural whey starters from the artisanal cheese industry. GABA is a non-protein amino acid widely distributed in nature and produced in animals, plants, and microorganisms. However, the best known role of GABA is its function as the major inhibitory neurotransmitter of the central nervous system. Preclinical and clinical evidence suggests that the GABAergic system has a relevant role in mental health disorders, such as anxiety and major depression. The modulation of the GABAergic system has been suggested as a potential strategy for treatment, one such mechanism of modulation is the influence of the microbiota-gut-brain axis through probiotic treatments. The present study was designed to investigate the in vivo probiotic potential of LPB145, a Lactiplantibacillus strain previously characterised as a GABA-producing potentially probiotic strain. Therefore, we evaluated the behavioural effects of chronic oral administration of LPB145 on rats' anxiety- and depression-like behaviours, using the elevated plus maze, open field, and the forced swimming test. The impact of LPB145 strain treatment on the gut microbiota structure and diversity was assessed to discern a possible mechanism of action of the LPB145 treatment through the microbiota-gut-brain axis. Our results showed that LPB145 administration induced an antidepressive-like behaviour without changes in locomotor activity. In contrast, the treatment did not modify the experimental anxiety. The structure and diversity of the intestinal microbiota remained unaffected by the treatment when compared to the control. However, specific clades that could be implicated in the behavioural changes did show differences in their relative abundance. These findings provide evidence regarding the potential of probiotic strains isolated from alimentary sources, to modulate the microbiota-gut-brain axis and positively impact mental health. © J. LOZANO et al., 2024. MenosABSTRACT.- In a previous study, we reported the in vitro potential probiotic and gamma-aminobutyric acid (GABA) production, of several strains from a collection of Lactiplantibacillus (Lpb) strains within the community of natural whey starters from the artisanal cheese industry. GABA is a non-protein amino acid widely distributed in nature and produced in animals, plants, and microorganisms. However, the best known role of GABA is its function as the major inhibitory neurotransmitter of the central nervous system. Preclinical and clinical evidence suggests that the GABAergic system has a relevant role in mental health disorders, such as anxiety and major depression. The modulation of the GABAergic system has been suggested as a potential strategy for treatment, one such mechanism of modulation is the influence of the microbiota-gut-brain axis through probiotic treatments. The present study was designed to investigate the in vivo probiotic potential of LPB145, a Lactiplantibacillus strain previously characterised as a GABA-producing potentially probiotic strain. Therefore, we evaluated the behavioural effects of chronic oral administration of LPB145 on rats' anxiety- and depression-like behaviours, using the elevated plus maze, open field, and the forced swimming test. The impact of LPB145 strain treatment on the gut microbiota structure and diversity was assessed to discern a possible mechanism of action of the LPB145 treatment through the microbiota-gut-brain axis. Our resu... Presentar Todo |
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Palabras claves : |
Depression; Gamma-aminobutyric acid; Intestinal microbiota; MGB axis; Natural whey starter; PLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA; Probiotic; Rats. |
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Asunto categoría : |
A50 Investigación agraria |
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Marc : |
LEADER 03533naa a2200325 a 4500
001 1064885
005 2024-10-21
008 2024 bl uuuu u00u1 u #d
022 $a1876-2891 (online)
024 7 $a10.1163/18762891-bja00024$2DOI
100 1 $aLOZANO, J.
245 $aBeneficial effect of GABA-producing Lactiplantibacillus strain LPB145 isolated from cheese starters evaluated in anxiety- and depression-like behaviours in rats.$h[electronic resource]
260 $c2024
500 $aArticle history: Received 21 October 2023, Accepted 19 June 2024, Published online 4 July 2024. -- Correspondence: Zunino, P.; Department of Microbiology, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay; email:pmzunino@gmail.com -- Published with license by Koninklijke Brill BV.
520 $aABSTRACT.- In a previous study, we reported the in vitro potential probiotic and gamma-aminobutyric acid (GABA) production, of several strains from a collection of Lactiplantibacillus (Lpb) strains within the community of natural whey starters from the artisanal cheese industry. GABA is a non-protein amino acid widely distributed in nature and produced in animals, plants, and microorganisms. However, the best known role of GABA is its function as the major inhibitory neurotransmitter of the central nervous system. Preclinical and clinical evidence suggests that the GABAergic system has a relevant role in mental health disorders, such as anxiety and major depression. The modulation of the GABAergic system has been suggested as a potential strategy for treatment, one such mechanism of modulation is the influence of the microbiota-gut-brain axis through probiotic treatments. The present study was designed to investigate the in vivo probiotic potential of LPB145, a Lactiplantibacillus strain previously characterised as a GABA-producing potentially probiotic strain. Therefore, we evaluated the behavioural effects of chronic oral administration of LPB145 on rats' anxiety- and depression-like behaviours, using the elevated plus maze, open field, and the forced swimming test. The impact of LPB145 strain treatment on the gut microbiota structure and diversity was assessed to discern a possible mechanism of action of the LPB145 treatment through the microbiota-gut-brain axis. Our results showed that LPB145 administration induced an antidepressive-like behaviour without changes in locomotor activity. In contrast, the treatment did not modify the experimental anxiety. The structure and diversity of the intestinal microbiota remained unaffected by the treatment when compared to the control. However, specific clades that could be implicated in the behavioural changes did show differences in their relative abundance. These findings provide evidence regarding the potential of probiotic strains isolated from alimentary sources, to modulate the microbiota-gut-brain axis and positively impact mental health. © J. LOZANO et al., 2024.
653 $aDepression
653 $aGamma-aminobutyric acid
653 $aIntestinal microbiota
653 $aMGB axis
653 $aNatural whey starter
653 $aPLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA
653 $aProbiotic
653 $aRats
700 1 $aFABIUS, S.
700 1 $aFERNÁNDEZ-CIGANDA, S.
700 1 $aURBANAVICIUS, J.
700 1 $aPICCINI, C.
700 1 $aSCORZA, C.
700 1 $aZUNINO, Z.
773 $tBeneficial Microbes, 2024, Volume 15, Issue 5, Pages 465-479. https://doi.org/10.1163/18762891-bja00024
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| 1. |  | Quincke, M. Trigos con genética INIA : distintas ofertas para distintas situaciones ln: "Uruguay. Instituto Nacional de Investigación Agropecuaria (INIA). Estación Experimental La Estanzuela ""Alberto Boerger""". Aportes a la zafra de cultivos de invierno. La Estanzuela: INIA, 2011. p. 47-53 Serie Actividades de Difusión ; 646 : Documentos Online ; 153 También disponible en versión electrónica| Biblioteca(s): INIA La Estanzuela; INIA Las Brujas. |
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| 4. | | SILVA, P.; QUINCKE, M.; GERMAN, S. Looking for new sources of partial resistance to wheat rusts in historical germplasm from South America. MV 18 - COMUNICACIONES LIBRES - MV. MEJORAMIENTO VEGETAL In: JOURNAL OF BASIC & APPLIED GENETICS, 2016, Vol.27, Iss. 1 (Supp.). XVI LATIN AMERICAN CONGRESS OF GENETICS, IV CONGRESS OF THE URUGUAYAN SOCIETY OF GENETICS, XLIX ANNUAL MEETING OF THE GENETICS SOCIETY OF CHILE, XLV ARGENTINE CONGRESS OF GENETICS, 9-12 October 2016. PROCEEDINGS. Montevideo (Uruguay): SAG, 2016. p. 289| Tipo: Trabajos en Congresos/Conferencias |
| Biblioteca(s): INIA Las Brujas. |
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| 6. | | GUTIÉRREZ, L.; LADO, B.; GONZÁLEZ, P.; SILVA, P.; QUINCKE, M. Handling Genotype-By-Environment Interaction in Genomic Selection to Predict New Genotypes and New Environments. [P0814] In: International Plant & Animal Genome, Conference PAG XXIV, "The largest Ag-genomics Meeting in the World San Diego, CA, USA; January 9-13, 2016. [Abstract] .| Tipo: Abstracts/Resúmenes |
| Biblioteca(s): INIA Las Brujas. |
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| 8. | | LADO, B.; VÁZQUEZ, D.; QUINCKE, M.; SILVA, P.; AGUILAR, I.; GUTIÉRREZ, L. Resource allocation optimization with multi-trait genomic prediction for bread wheat (Triticum aestivum L.) baking quality. [Original article]. Theoretical and Applied Genetics, 1 December 2018, Volume 131, Issue 12, pp. 2719-2731. OPEN ACCESS. Article history: Received: 29 January 2018 / Accepted: 10 September 2018 / Published online: 19 September 2018.
Supplementary materials.
Acknowledgements: We express our appreciation for the effort of the technical personnel of INIA La...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Las Brujas. |
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| 10. | | GERMAN, S.; QUINCKE, M.; VÁZQUEZ, D.; CASTRO, M.; PEREYRA, S.; SILVA, P.; GARCIA, A. (Ed.). Seminario Internacional "1914-2014: Un siglo de mejoramiento de trigo en La Estanzuela." INIA La Estanzuela, 27-28-29 de agosto de 2014. Montevideo (UY): INIA, 2018. 307 p. (INIA Serie Técnica; 241) Editores y Comité Organizador: Silvia Germán, Martín Quincke, Daniel Vázquez, Marina Castro, Silvia Pereyra, Paula Silva, Adriana García.| Biblioteca(s): INIA La Estanzuela; INIA Las Brujas. |
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| 11. | | ESTEVES, P.; HERNANDEZ, L.; CASTILLO, A.; DALLA RIZZA, M.; QUINCKE, M. Tecnologías para el desarrollo de líneas recombinantes de trigo. MV 20 - COMUNICACIONES LIBRES - MV. MEJORAMIENTO VEGETAL In: JOURNAL OF BASIC & APPLIED GENETICS, 2016, Vol.27, Iss. 1 (Supp.). XVI LATIN AMERICAN CONGRESS OF GENETICS, IV CONGRESS OF THE URUGUAYAN SOCIETY OF GENETICS, XLIX ANNUAL MEETING OF THE GENETICS SOCIETY OF CHILE, XLV ARGENTINE CONGRESS OF GENETICS, 9-12 October 2016. PROCEEDINGS. Montevideo (Uruguay): SAG, 2016. p. 290| Tipo: Trabajos en Congresos/Conferencias |
| Biblioteca(s): INIA Las Brujas. |
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| 12. | | ESTEVES, P.; MASTROPIERRO, M.; CASTILLO, A.; HERNANDEZ, L.; RODRIGUEZ, M.; DE LEON, W.; PEREIRA, F.; QUINCKE, M. Herramientas biotecnológicas para el mejoramiento genético de cultivos. Revista INIA Uruguay, 2017, no.48, p. 62-66. (Revista INIA; 48)| Tipo: Artículos en Revistas Agropecuarias |
| Biblioteca(s): INIA Las Brujas; INIA Tacuarembó. |
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| 13. | | QUINCKE, M.; PETERSON, C.J.; ZEMETRA, R.S.; HANSEN, J.L.; CHEN, J.; RIERA-LIZARAZU, O.; MUNDT, C.C. Quantitative trait loci analysis for resistance to cephalosporium stripe, a vascular wilt disease of wheat. Theoretical and Applied Genetics, 2011, v.122, No.7, p.1339-1349. Article history: Received: 20 August 2010 / Accepted: 6 January 2011 / Published online: 23 January 2011.| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : A - 1 |
| Biblioteca(s): INIA La Estanzuela; INIA Las Brujas. |
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| 14. | | SILVA, P.; CALVO-SALAZAR, V.; CONDON, F.; QUINCKE, M.; PRITSCH, C.; GUTIÉRREZ, L.; CASTRO, A.; HERRERA-FOESSEL, S.; VON ZITZEWITZ, J.; GERMAN, S. Effects and interactions of genes Lr34, Lr68 and Sr2 on wheat leaf rust adult plant resistance in Uruguay Euphytica, 2015, v. 204, p. 599?608.| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA La Estanzuela; INIA Las Brujas. |
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| 15. | | RAFFO, M.A.; PRITSCH, C.; AZZIMONTI, G.; PEREYRA, S.; QUINCKE, M.; BONNECARRERE, V.; SILVA, P.; CASTRO, A.; LADO, B.; BARAIBAR, S.; PEREYRA, S.; GERMAN, S. Introducción de Fhb1 en germoplasma elite de trigo para incrementar la resistencia a fusariosis de espiga en Uruguay. [p24]. Bloque 2: Mejoramiento por resistencia a enfermedades. In: Sociedad Uruguaya de Fitopatología Jornada Uruguaya de Fitopatología, 4., Jornada Uruguaya de Protección Vegetal, 2., 1° setiembre, 2017, Montevideo, Uruguay. Libro de resúmenes. Montevideo (UY): Sociedad Uruguay de Fitopatología (SUFIT), 2017. p. 44. Financiamiento: Agencia Nacional de Investigación e Innovación (POS_NAC_2016_1_129877).| Tipo: Abstracts/Resúmenes |
| Biblioteca(s): INIA Las Brujas. |
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| 16. | | LADO, B.; BATTENFIELD, S. D.; GUZMÁN, C.; QUINCKE, M.; SINGH, R. P.; DREISIGACKER, S.; PEÑA, R. J.; FRITZ, AL.; SILVA, P.; POLAND, J.; GUTIÉRREZ, L. Strategies for selecting crosses using genomic prediction in two wheat breeding programs. The Plant Genome, 2017, v.10, Issue 2, 12p. OPEN ACCESS Article history: Received: Dec 14, 2016 // Accepted: Mar 18, 2017 // Published: July 6, 2017.
B. Lado and S. Battenfield contributed equally.Assigned to Associate Editor Nicholas Tinker.
This is an open access article distributed under...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Las Brujas. |
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| 17. | | PEREYRA, S.; CASTRO, M.; VERO, S.; SILVA, P.; CAL, A.; TISCORNIA, G.; GONZALEZ, N.; BENTOS, D.; ALVAREZ, W.; RABAZA, S.; SEVILLANO, L.; BRANCATTI, G.; FRANCIA, C.; RAFFO, M.A.; GERMAN, S.; PÉREZ, C.; GARMENDIA, G.; PAREJA, L.; RODRÍGUEZ, A.; PENDAS, C.; QUINCKE, M.; VÁZQUEZ, D.; RODRIGUEZ, M. Fusariosis de la espiga en trigo y micotoxinas asociadas: contribuyendo a reducir su riesgo. Cultivos. Revista INIA Uruguay, Diciembre 2023, no.75 p.54-58. (Revista INIA; 75).| Tipo: Artículos en Revistas Agropecuarias |
| Biblioteca(s): INIA Las Brujas. |
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| 18. | | LANGRIDGE, P.; ALAUX, M.; ALMEIDA, N.F.; AMMAR, K.; BAUM, M.; BEKKAOUI, F.; BENTLEY, A.R.; BERES, B.L.; BERGER, B.; BRAUN, H.-J.; BROWN-GUEDIRA, G.; BURT, C.J.; CACCAMO, M.J.; CATTIVELLI, L.; CHARMET, G.; CIVÁN, P.; CLOUTIER, S.; COHAN, J-P.; DEVAUX, P.; DOOHAN, F.M.; DRECCER, M.F.; FERRAHI, M.; GERMAN, S.; GOODWIN, S.B.; GRIFFITHS, S.; GUZMÁN, C.; HANDA, H.; HAWKESFORD, M.J.; HE, Z.; HUTTNER, E.; IKEDA, T.M.; KILIAN, B.; KING, I.P.; KING, J.; KIRKEGAARD, J.A.; LAGE, J.; LE GOUIS, J.; MONDAL, S.; MULLINS, E.; ORDON, F.; ORTIZ-MONASTERIO, J.I.; ÖZKAN, H.; ÖZTÜRK, I.; PEREYRA, S.; POZNIAK, C.J.; QUESNEVILLE, H.; QUINCKE, M.; REBETZKE, G.J.; CHRISTOPH REIF, J.; SAAVEDRA-BRAVO, T.; SCHURR, U.; SHARMA, S.; SINGH, S.K.; SINGH, R.P.; SNAPE, J.W.; TADESSE, W.; TSUJIMOTO, H.; TUBEROSA, R.; WILLIS, T.G.; ZHANG, X. Meeting the challenges facing wheat production: the strategic research agenda of the Global Wheat Initiative. Agronomy, 2022, volume 12, issue 11, 2767. OPEN ACCESS. doi: https://doi.org/10.3390/agronomy12112767 Article history: Received 26 September 2022; Revised 28 October 2022; Accepted 29 October 2022; Published 7 November 2022. -- Academic Editor: Andreas Katsiotis. -- Corresponding author: Langridge, P.; School of Agriculture, Food and...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Las Brujas. |
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| Registros recuperados : 18 | |
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