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 | Acceso al texto completo restringido a Biblioteca INIA La Estanzuela. Por información adicional contacte bib_le@inia.org.uy. |
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Registro completo
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Biblioteca (s) : |
INIA La Estanzuela. |
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Fecha : |
02/03/2017 |
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Actualizado : |
07/03/2017 |
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Autor : |
GARCIA, J.P; GIANNITTI, F.; FINNIE, J.W.; MANAVIS, J. .; BEINGESSER, J.; ADAMS ,V.; ROOD, J.I.; UZAL, F.A. |
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Afiliación : |
FEDERICO GIANNITTI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
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Título : |
Comparative Neuropathology of Ovine Enterotoxemia Produced by Clostridium perfringens Type D Wild-Type Strain CN1020 and Its Genetically Modified Derivatives. |
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Fecha de publicación : |
2015 |
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Fuente / Imprenta : |
Veterinary Pathology, 2015, v.52.n.6. p.1250-1253, 2015. |
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Idioma : |
Inglés |
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Contenido : |
Abstract
Clostridium perfringens type D causes enterotoxemia in sheep and goats. The disease is mediated by epsilon toxin (ETX), which affects the cerebrovascular endothelium, increasing vascular permeability and leading to cerebral edema. In the present study, we compared the distribution and severity of the cerebrovascular changes induced in lambs by C. perfringens type D strain CN1020, its isogenic etx null mutant, and the ETX-producing complemented mutant. We also applied histochemical and immunohistochemical markers to further characterize the brain lesions induced by ETX. Both ETX-producing strains induced extensive cerebrovascular damage that did not differ significantly between each other in nature, neuroanatomic distribution, or severity. By contrast, lambs inoculated with the etx mutant or sterile, nontoxic culture medium did not develop detectable brain lesions, confirming that the neuropathologic effects observed in these infections are dependent on ETX production. Lambs treated with the wild-type and complemented strains showed perivascular and mural vascular edema, as well as serum albumin extravasation, particularly severe in the cerebral white matter, midbrain, medulla oblongata, and cerebellum. Brains of animals inoculated with the ETX-producing strains showed decreased expression of glial fibrillary acidic protein and increased expression of aquaporin-4 in the end-feet processes of the astrocytes around blood vessels. Early axonal injury was demonstrated with anti?amyloid precursor protein immunohistochemistry. Perivascular accumulation of macrophages/microglia with intracytoplasmic albumin globules was also observed in these animals. This study demonstrates that ETX is responsible for the major cerebrovascular changes in C. perfringens type D?induced disease. MenosAbstract
Clostridium perfringens type D causes enterotoxemia in sheep and goats. The disease is mediated by epsilon toxin (ETX), which affects the cerebrovascular endothelium, increasing vascular permeability and leading to cerebral edema. In the present study, we compared the distribution and severity of the cerebrovascular changes induced in lambs by C. perfringens type D strain CN1020, its isogenic etx null mutant, and the ETX-producing complemented mutant. We also applied histochemical and immunohistochemical markers to further characterize the brain lesions induced by ETX. Both ETX-producing strains induced extensive cerebrovascular damage that did not differ significantly between each other in nature, neuroanatomic distribution, or severity. By contrast, lambs inoculated with the etx mutant or sterile, nontoxic culture medium did not develop detectable brain lesions, confirming that the neuropathologic effects observed in these infections are dependent on ETX production. Lambs treated with the wild-type and complemented strains showed perivascular and mural vascular edema, as well as serum albumin extravasation, particularly severe in the cerebral white matter, midbrain, medulla oblongata, and cerebellum. Brains of animals inoculated with the ETX-producing strains showed decreased expression of glial fibrillary acidic protein and increased expression of aquaporin-4 in the end-feet processes of the astrocytes around blood vessels. Early axonal injury was demonstrated wi... Presentar Todo |
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Thesagro : |
ENFERMEDADES DE LOS ANIMALES. |
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Asunto categoría : |
-- |
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Marc : |
LEADER 02512naa a2200217 a 4500
001 1056750
005 2017-03-07
008 2015 bl uuuu u00u1 u #d
100 1 $aGARCIA, J.P
245 $aComparative Neuropathology of Ovine Enterotoxemia Produced by Clostridium perfringens Type D Wild-Type Strain CN1020 and Its Genetically Modified Derivatives.$h[electronic resource]
260 $c2015
520 $aAbstract Clostridium perfringens type D causes enterotoxemia in sheep and goats. The disease is mediated by epsilon toxin (ETX), which affects the cerebrovascular endothelium, increasing vascular permeability and leading to cerebral edema. In the present study, we compared the distribution and severity of the cerebrovascular changes induced in lambs by C. perfringens type D strain CN1020, its isogenic etx null mutant, and the ETX-producing complemented mutant. We also applied histochemical and immunohistochemical markers to further characterize the brain lesions induced by ETX. Both ETX-producing strains induced extensive cerebrovascular damage that did not differ significantly between each other in nature, neuroanatomic distribution, or severity. By contrast, lambs inoculated with the etx mutant or sterile, nontoxic culture medium did not develop detectable brain lesions, confirming that the neuropathologic effects observed in these infections are dependent on ETX production. Lambs treated with the wild-type and complemented strains showed perivascular and mural vascular edema, as well as serum albumin extravasation, particularly severe in the cerebral white matter, midbrain, medulla oblongata, and cerebellum. Brains of animals inoculated with the ETX-producing strains showed decreased expression of glial fibrillary acidic protein and increased expression of aquaporin-4 in the end-feet processes of the astrocytes around blood vessels. Early axonal injury was demonstrated with anti?amyloid precursor protein immunohistochemistry. Perivascular accumulation of macrophages/microglia with intracytoplasmic albumin globules was also observed in these animals. This study demonstrates that ETX is responsible for the major cerebrovascular changes in C. perfringens type D?induced disease.
650 $aENFERMEDADES DE LOS ANIMALES
700 1 $aGIANNITTI, F.
700 1 $aFINNIE, J.W.
700 1 $aMANAVIS, J. .
700 1 $aBEINGESSER, J.
700 1 $aADAMS ,V.
700 1 $aROOD, J.I.
700 1 $aUZAL, F.A.
773 $tVeterinary Pathology, 2015$gv.52.n.6. p.1250-1253, 2015.
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| Registros recuperados : 14 | |
| 1. |  | PRINGLES, M.; CORALLO, B.; STEWART, S.; PAN, D. P6. Producción de celulasas por especies de Fusarium aisladas de sorgo. [Poster]. Posters. In: Sociedad Uruguaya de Fitopatología (SUFIT). Jornada Uruguaya de Fitopatología, 7., Jornada Uruguaya de Protección Vegetal, 5., 10 noviembre 2023, Montevideo, Uruguay. Libro de resúmenes. 30 años SUFIT, 1993-2023. Montevideo (UY): Sociedad Uruguay de Fitopatología (SUFIT), 2023. p. 33. Financiamiento: Proyecto CSIC I+D 2020 "Patogenicidad y toxicidad de especies de Fusarium y su efecto en el rendimiento del cultivo de sorgo y la inocuidad de los granos". -- Autor correspondencia: e-mail: dpan@fing.edu.uy| Tipo: Abstracts/Resúmenes |
| Biblioteca(s): INIA Las Brujas. |
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| 2. | | COSTA, A.; CORALLO, B.; AMARELLE, V.; ROLDÁN, D.; STEWART, S.; PAN, D.; TISCORNIA, S.; FABIANO, E. Análisis in vitro e in silico de la actividad antimicrobiana ejercida por la cepa Paenibacillus sp. UY79, aislada de nódulo de raíz de Arachis villosa. [resumen]. Resúmenes Sesión 2: Promoción indirecta del crecimiento vegetal. In: Reunión Latinoamericana de Rizobiología, XXX; Conferencia Latinoamericana de microorganismos promotores del crecimiento vegetal, V., Montevideo (Uruguay), 4-8 octubre 2021. Memoria RELAR-PGPR-2021. p.42. Expone: Costa, A. -- Contacto: andrescosta1991@gmail.com --| Tipo: Abstracts/Resúmenes |
| Biblioteca(s): INIA Las Brujas. |
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| 3. | | COSTA, A.; CORALLO, B.; AMARELLE, A.; TISCORNIA, S.; STEWART, S.; PAN, D.; FABIANO, E. Bacillus sp. UY6A, una cepa aislada de nódulo de Lupinus multiflorus con características promisorias como agente de control biológico. P9. [abstract + poster]. Módulo 3: Nuevas estrategias para potenciar el control biológico. In: Abreo, E.; Beyhaut, E.; Rivas, F. (Eds.). Simposio Microorganismos para la Agricultura, 2. [Resúmenes y Posters]. Canelones (UY): INIA, 2022. p.25. (Serie Actividades de Difusión; 801). Financiación: FONTAGRO ID30, Pedeciba Química-Biología.| Tipo: Abstracts/Resúmenes |
| Biblioteca(s): INIA Las Brujas. |
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| 5. | | CORALLO, B.; SIMETO, S.; MARTÍNEZ, G.; GÓMEZ, D.; ABREO, E.; ALTIER, N.; LUPO, S. Entomopathogenic fungi naturally infecting the eucalypt bronze bug, Thaumastocoris peregrinus (Heteroptera: Thaumastocoridae), in Uruguay. Journal of Applied Entomology, 2019, p.1-14. Article history: Received: 7 November 2018 / Revised: 8 February 2019 / Accepted: 10 February 2019.
Funding information: Comisión Académica de Posgrado, Beauveria pseudobassiana; INIA, Grant/Award Number: FO_18| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Las Brujas; INIA Tacuarembó. |
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| 6. | | STEWART, S.; BENTOS, D.; RODRIGUEZ, M.; CORALLO, B.; PONCE DE LEÓN, I.; PAN, D. Impact of pathogenic Fusarium species on sorghum in Uruguay. International Journal of Pest Management, 2024. https://doi.org/10.1080/09670874.2024.2435607 Article history: Received 2 May 2024, Accepted 24 November 2024, Published online 06 Dec 2024. -- Corresponding: Silvina Stewart, sstewart@inia.org.uy Sistema Agrícola-Ganadero, Instituto Nacional de Investigación Agropecuaria, Colonia,...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Las Brujas. |
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| 7. | | STEWART, S.; CORALLO, B.; BENTOS, D.; PONCE DE LEÓN, I.; PAN, D. P10. Patogenicidad de Fusarium spp. en sorgo. [Poster]. Posters. In: Sociedad Uruguaya de Fitopatología (SUFIT). Jornada Uruguaya de Fitopatología, 7., Jornada Uruguaya de Protección Vegetal, 5., 10 noviembre 2023, Montevideo, Uruguay. Libro de resúmenes. 30 años SUFIT, 1993-2023. Montevideo (UY): Sociedad Uruguay de Fitopatología (SUFIT), 2023. p. 37. Financiamiento: Proyecto CSIC I+D 2020 "Patogenicidad y toxicidad de especies de Fusarium y su efecto en el rendimiento del cultivo de sorgo y la inocuidad de los granos". -- Autor correspondencia: e-mail: sstewart@inia.org.uy| Tipo: Abstracts/Resúmenes |
| Biblioteca(s): INIA Las Brujas. |
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| 8. | | CORALLO, B.; MENA, E.; STEWART, S.; PONCE DE LEÓN, I.; PAN, D. P2. Expresión de genes de Fusarium graminearum implicados en la producción de toxinas. [Poster] Posters. In: Sociedad Uruguaya de Fitopatología (SUFIT). Jornada Uruguaya de Fitopatología, 7., Jornada Uruguaya de Protección Vegetal, 5., 10 noviembre 2023, Montevideo, Uruguay. Libro de resúmenes. 30 años SUFIT, 1993-2023. Montevideo (UY): Sociedad Uruguay de Fitopatología (SUFIT), 2023. p. 29. Financiamiento: proyecto CSIC I+D 2020. -- Autor correspondencia: e-mail: bcorallo@fcien.edu.uy| Tipo: Abstracts/Resúmenes |
| Biblioteca(s): INIA Las Brujas. |
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| 9. | | COSTA, A.; CORALLO, B.; AMARELLE, V.; STEWART, S.; PAN, D.; TISCORNIA, S.; FABIANO, E. Paenibacillus sp. strain UY79, isolated from a root nodule of Arachis villosa, displays a broad spectrum of antifungal activity. Applied and Environmental Microbiology, 2022, Volume 88. Issue 2, e01645-21. doi: https://doi.org/10.1128/AEM.01645-21 Article history:| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Las Brujas. |
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| 10. | | STEWART, S.; RODRIGUEZ, M.; CORALLO, B.; DEL PALACIO, A.; CEA, J.; SIMOENS, M.; SANCHEZ, A.; PAN, D. Explorando prácticas de manejo que tiendan a minimizar la contaminación de micotoxinas producidas por Fusarium spp. en sorgo y maíz. In: Sociedad Uruguaya de Fitopatología Jornada Uruguaya de Fitopatología, 6., Jornada Uruguaya de Protección Vegetal, 4., 21-22 octubre, 2021, Montevideo, Uruguay. Libro de resúmenes. Montevideo (UY): Sociedad Uruguay de Fitopatología (SUFIT), 2021. p. 52. Financiamiento: Proyecto INNOVAGRO ANII FSA-I-2017-1-139531.| Tipo: Abstracts/Resúmenes |
| Biblioteca(s): INIA La Estanzuela. |
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| 11. | | SIMETO, S.; CORALLO, B.; LUPO, S.; BETTUCCI, L.; GÓMEZ, D.; GONZALEZ, P.; MARTÍNEZ, G.; ABREO, E.; RIVAS, F.; ALTIER, N. Biological control of Thaumastocoris peregrinus Carpintero and Dellappé (Heteroptera: Thaumastocoridae): towards the development of a mycoinsecticide. [Resumen]. In: Anniversary Congress, 125th, 19-22 September, Freiburg, Germany, 2017. p. 187| Biblioteca(s): INIA Tacuarembó. |
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| 12. | | DEL PALACIO, A.; CORALLO, B.; CEA, J.; DE AURRECOECHEA, I.; MARTÍNEZ, I.; SÁNCHEZ, A.; STEWART, S.; PAN, D. Major Fusarium species and mycotoxins associated with freshly harvested maize grain in Uruguay. Mycotoxin Research. 2023, https://doi.org/10.1007/s12550-023-00498-y -- [Article in Press]. Article history: Received 5 December 2022, Revised 22 May 2023, Accepted 27 June 2023. -- Correspondence author: Pan, D.; Laboratorio de Micología, Facultad de Ciencias-Facultad de Ingeniería, UdelaR, Julio Herreray Reissig, Montevideo,...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Las Brujas. |
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| 13. | | SIMETO, S.; LUPO, S.; BETTUCCI, L.; CORALLO, B.; GOMEZ, D.; GONZALEZ, P.; TORRES, D.; MARTINEZ, G.; ABREO, E.; RIVAS, F.; ALTIER, N. Desarrollo de bioinsecticidas (hongos entomopatógenos) para el control de la chinche del eucalipto Thaumastocoris peregrinus Proyecto INIA FO18, Plan Estratégico Institucional 2011-2015. ln: Abreo, E.; Altier, N.; comp. Taller de Agentes Microbianos de Control Biológico, 4., Resúmenes de presentaciones. Montevideo, 31 Octubre, 2014. Montevideo: INIA. UDELAR. PROCISUR. p. 17| Tipo: Trabajos en Congresos/Conferencias |
| Biblioteca(s): INIA Tacuarembó. |
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| 14. | | SIMETO, S.; LUPO, S.; BETTUCCI, L.; CORALLO, B.; PEREZ, C.; GÓMEZ, D.; GONZALEZ, P.; TORRES, D.; MARTÍNEZ, G.; ABREO, E.; RIVAS, F.; ALTIER, N. Hongos entomopatógenos para el control de la chinche del eucalipto Thaumastocoris peregrinus: resultados preliminares. In: JORNADA TÉCNICA DE PROTECCIÓN FORESTAL, 6., 2013, TACUAREMBÓ, UY; BALMELLI, G.; SIMETO, S.; MARTINEZ, G.; GOMEZ, D. (Ed.). Montevideo, UY: INIA, 2014. 27-37 (INIA Serie Técnica; 213)| Tipo: Capítulo en Libro Técnico-Científico |
| Biblioteca(s): INIA Tacuarembó. |
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| Registros recuperados : 14 | |
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