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 | Acceso al texto completo restringido a Biblioteca INIA Las Brujas. Por información adicional contacte bibliolb@inia.org.uy. |
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha : |
11/04/2017 |
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Actualizado : |
09/10/2019 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
DALLA RIZZA, M.; DIAZ, P.; NARANCIO, R.; CABRERA, A.; FERREIRA, F. |
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Afiliación : |
MARCO DALLA RIZZA VILARO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; PAOLA ALEXANDRA DIAZ DELLAVALLE, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; RAFAEL NARANCIO FERES, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ANDREA CECILIA CABRERA BARRIOS, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; FERNANDO FERREIRA, Universidad de la República (UdelaR)/ Facultad de Química. |
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Título : |
Biomolecules as host defense weapons against microbial pathogens. (Review) |
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Fecha de publicación : |
2008 |
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Fuente / Imprenta : |
Recent Patents on DNA and Gene Sequences, 2008, v.2, no.2, p.82-96. |
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ISSN : |
1872-2156 |
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DOI : |
10.2174/187221508784534186 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received: April 21, 2008 / Accepted: April 29, 2008 / Revised: April 29, 2008. |
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Contenido : |
ABSTRACT.
Antimicrobial peptides have been considered a new source of biomolecules in several fields of research/innovative applications: they would adjust to an ideal behavior seeking to overcome clinician, microbiological, human-animal-plant-environmental concerns. Antimicrobial peptides can be considered as ancient weapons found in living organisms suggesting they have played a fundamental role in his successful co-evolution with pathogens. Acting on microorganism membrane or having intracellular targets, they can also act as effectors of the innate immune response resulting on non-specific mechanisms of action. Two elements have speeded the research on pathogen control alternatives: a verified increase of antibiotic resistance and the relevance of finding amenable environmental compounds in plant health. As a result of its importance, great efforts have been accomplished to find, characterize, combine and synthesize effective antimicrobial peptides. This review intends to emphasize the generation of biomolecules, whether native or synthetic analogues, that have been matter of recent patents. Development of biomolecules suitable for therapeutic scopes and agricultural use have several challenges such as intrinsic toxicity, in vivo stability and suitable formulation contemplating the cost of production. Thus, biotechnological procedures using microbial systems or transgenic crops as plant factories might help to solve these challenges.
© 2008 Bentham Science Publishers Ltd. MenosABSTRACT.
Antimicrobial peptides have been considered a new source of biomolecules in several fields of research/innovative applications: they would adjust to an ideal behavior seeking to overcome clinician, microbiological, human-animal-plant-environmental concerns. Antimicrobial peptides can be considered as ancient weapons found in living organisms suggesting they have played a fundamental role in his successful co-evolution with pathogens. Acting on microorganism membrane or having intracellular targets, they can also act as effectors of the innate immune response resulting on non-specific mechanisms of action. Two elements have speeded the research on pathogen control alternatives: a verified increase of antibiotic resistance and the relevance of finding amenable environmental compounds in plant health. As a result of its importance, great efforts have been accomplished to find, characterize, combine and synthesize effective antimicrobial peptides. This review intends to emphasize the generation of biomolecules, whether native or synthetic analogues, that have been matter of recent patents. Development of biomolecules suitable for therapeutic scopes and agricultural use have several challenges such as intrinsic toxicity, in vivo stability and suitable formulation contemplating the cost of production. Thus, biotechnological procedures using microbial systems or transgenic crops as plant factories might help to solve these challenges.
© 2008 Bentham Science Publishers ... Presentar Todo |
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Palabras claves : |
ANTIMICROBIAL; BIOCONTROL AGENTS; MODES OF ACTION; PEPTIDES. |
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Thesagro : |
AGENTES DE CONTROL BIOLOGICO; ANTIMICROBIANOS; PEPTIDOS. |
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Asunto categoría : |
-- |
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Marc : |
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022 $a1872-2156
024 7 $a10.2174/187221508784534186$2DOI
100 1 $aDALLA RIZZA, M.
245 $aBiomolecules as host defense weapons against microbial pathogens. (Review)$h[electronic resource]
260 $c2008
500 $aArticle history: Received: April 21, 2008 / Accepted: April 29, 2008 / Revised: April 29, 2008.
520 $aABSTRACT. Antimicrobial peptides have been considered a new source of biomolecules in several fields of research/innovative applications: they would adjust to an ideal behavior seeking to overcome clinician, microbiological, human-animal-plant-environmental concerns. Antimicrobial peptides can be considered as ancient weapons found in living organisms suggesting they have played a fundamental role in his successful co-evolution with pathogens. Acting on microorganism membrane or having intracellular targets, they can also act as effectors of the innate immune response resulting on non-specific mechanisms of action. Two elements have speeded the research on pathogen control alternatives: a verified increase of antibiotic resistance and the relevance of finding amenable environmental compounds in plant health. As a result of its importance, great efforts have been accomplished to find, characterize, combine and synthesize effective antimicrobial peptides. This review intends to emphasize the generation of biomolecules, whether native or synthetic analogues, that have been matter of recent patents. Development of biomolecules suitable for therapeutic scopes and agricultural use have several challenges such as intrinsic toxicity, in vivo stability and suitable formulation contemplating the cost of production. Thus, biotechnological procedures using microbial systems or transgenic crops as plant factories might help to solve these challenges. © 2008 Bentham Science Publishers Ltd.
650 $aAGENTES DE CONTROL BIOLOGICO
650 $aANTIMICROBIANOS
650 $aPEPTIDOS
653 $aANTIMICROBIAL
653 $aBIOCONTROL AGENTS
653 $aMODES OF ACTION
653 $aPEPTIDES
700 1 $aDIAZ, P.
700 1 $aNARANCIO, R.
700 1 $aCABRERA, A.
700 1 $aFERREIRA, F.
773 $tRecent Patents on DNA and Gene Sequences, 2008$gv.2, no.2, p.82-96.
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| 1. |  | BLANCO, C.A.; CHIARAVALLE, W.; DALLA RIZZA, M.; FARÍAS, J.R.; GARCÍA-DEGANO, M.F.; GASTAMINZA, G.; MOTA-SÁNCHEZ, D.; MURÚA, M.G.; OMOTO, C.; PIERALISI, B.K.; RODRÍGUEZ, J.; RODRÍGUEZ-MACIEL, J.C.; TERÁN-SANTOFIMIO, H.; TERÁN-VARGAS, A.P.; VALENCIA, S.J.; WILLINK, E. Current situation of pests targeted by Bt crops in Latin America. Current Opinion in Insect Science, 2016, v.15, p. 131-138. This review comes from a themed issue on Pests and resistance Edited by Blair Siegfried and Juan Luis Jurat-Fuentes. For a complete overview see the Issue and the Editorial
Available online 10th May 2016.| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Las Brujas. |
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