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 | Acceso al texto completo restringido a Biblioteca INIA La Estanzuela. Por información adicional contacte bib_le@inia.org.uy. |
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Registro completo
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Biblioteca (s) : |
INIA La Estanzuela. |
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Fecha : |
09/08/2019 |
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Actualizado : |
27/01/2020 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
MACHADO, M.; MIGUEL, M.P.; TERRA, J.P.; FERREIRA, J.A. JR; RIET-CORREA, F.; DE CASTRO, M.B. |
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Afiliación : |
MIZAEL MACHADO, Veterinary Pathology Laboratory, Veterinary Teaching Hospital,Via L4 Norte, Sn/, Universidade de Brasília (UnB), Campus Universitário Darcy Ribeiro, 70636-200, Brasília, Distrito Federal, Brazil.; MARINA PACHECO MIGUEL, Instituto de Patologia Tropical e Saúde Pública, UFG, Rua 235 S/n, Setor Universitário, 74605-050, Goiânia, Goiás, Brazil.; JULIANO PEREIRA TERRA, Instituto Federal Catarinense, Campus Araquari, Rodovia BR 280 - Km 27 - Cx. Postal 21, Porto Grande, 89245000, Araquari, SC, Brazil.; JAIR ALVES FERREIRA JR., Veterinary Pathology Laboratory, Veterinary Teaching Hospital,Via L4 Norte, Sn/, Universidade de Brasília (UnB), Campus Universitário Darcy Ribeiro, 70636-200, Brasília, Distrito Federal, Brazil.; FRANKLIN RIET-CORREA AMARAL, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MÁRCIO BOTELHO DE CASTRO, Veterinary Pathology Laboratory, Veterinary Teaching Hospital,Via L4 Norte, Sn/, Universidade de Brasília (UnB), Campus Universitário Darcy Ribeiro, 70636-200, Brasília, Distrito Federal, Brazil. |
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Título : |
Acute fatal poisoning by spontaneous ingestion of Enterolobium contortisiliquum (Mimosidae) pods in horses. |
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Fecha de publicación : |
2019 |
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Fuente / Imprenta : |
Toxicon, v. 168, p.122-125, Jul 2019. |
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DOI : |
10.1016/j.toxicon.2019.07.006 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received 25 March 2019// Revised 12 July 2019// Accepted 16 July 2019// Available online 19 July 2019. |
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Contenido : |
Abstract:
An outbreak of acute poisoning of horses by Enterolobium contortisiliquum pods is reported in the state of Goiás, Brazil. Three horses presented apathy, hyporexia, prostration, jaundice, recumbency and died in 24-48 hours. The main pathological findings were a yellowish liver with an enhanced lobular pattern, multifocal hepatic necrosis mostly in the midzones of lobules and sometimes with a random distribution across the hepatic lobes and swelling of hepatocytes. E. contortisiliquum trees has a wide distribution in South America and cases of poisoning have not been reported in horses. |
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Palabras claves : |
ENTEROLOBIUM CONTORTISILIQUUM PODS; EQUINE; HEPATIC NECROSIS; PLANTAS VENENOSAS; PLATAFORMA SALUD ANIMAL; POISONOUS PLANTS. |
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Thesagro : |
EQUINOS; NECROSIS. |
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Asunto categoría : |
-- |
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Marc : |
LEADER 01596naa a2200301 a 4500
001 1059999
005 2020-01-27
008 2019 bl uuuu u00u1 u #d
024 7 $a10.1016/j.toxicon.2019.07.006$2DOI
100 1 $aMACHADO, M.
245 $aAcute fatal poisoning by spontaneous ingestion of Enterolobium contortisiliquum (Mimosidae) pods in horses.$h[electronic resource]
260 $c2019
500 $aArticle history: Received 25 March 2019// Revised 12 July 2019// Accepted 16 July 2019// Available online 19 July 2019.
520 $aAbstract: An outbreak of acute poisoning of horses by Enterolobium contortisiliquum pods is reported in the state of Goiás, Brazil. Three horses presented apathy, hyporexia, prostration, jaundice, recumbency and died in 24-48 hours. The main pathological findings were a yellowish liver with an enhanced lobular pattern, multifocal hepatic necrosis mostly in the midzones of lobules and sometimes with a random distribution across the hepatic lobes and swelling of hepatocytes. E. contortisiliquum trees has a wide distribution in South America and cases of poisoning have not been reported in horses.
650 $aEQUINOS
650 $aNECROSIS
653 $aENTEROLOBIUM CONTORTISILIQUUM PODS
653 $aEQUINE
653 $aHEPATIC NECROSIS
653 $aPLANTAS VENENOSAS
653 $aPLATAFORMA SALUD ANIMAL
653 $aPOISONOUS PLANTS
700 1 $aMIGUEL, M.P.
700 1 $aTERRA, J.P.
700 1 $aFERREIRA, J.A. JR
700 1 $aRIET-CORREA, F.
700 1 $aDE CASTRO, M.B.
773 $tToxicon$gv. 168, p.122-125, Jul 2019.
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Registro original : |
INIA La Estanzuela (LE) |
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha actual : |
30/06/2023 |
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Actualizado : |
30/06/2023 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Circulación / Nivel : |
Internacional - -- |
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Autor : |
GIANNITTI, F.; GARCÍA, J. P.; ADAMS, V.; ARMENDANO, J.; BEINGESSER, J.; ROOD, J.; UZAL, F. A. |
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Afiliación : |
FEDERICO GIANNITTI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; JORGE P. GARCÍA, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Buenos Aires, Argentina; VICKI ADAMS, Monash University, Parkville, Victoria, Australia; JOAQUÍN I. ARMENDANO, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Buenos Aires, Argentina; JULIANN BEINGESSER, California Animal Health and Food Safety Laboratoy, University of California at Davis, San Bernardino, CA; JULIAN I. ROOD, Monash University, Parkville, Victoria, Australia; FRANCISCO A. UZAL, Monash University, Parkville, Victoria, Australia. |
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Título : |
Experimental acute Clostridium perfringens type D enterotoxemia in sheep is not characterized by specific renal lesions. |
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Complemento del título : |
Infectious Disease - Original Article. |
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Fecha de publicación : |
2023 |
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Fuente / Imprenta : |
Veterinary Pathology. 2023, vol.60(4):412-419. https://doi.org/10.1177/03009858231171669 |
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ISSN : |
0300-9858 (print); 1544-2217 (online). |
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DOI : |
10.1177/03009858231171669 |
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Idioma : |
Inglés |
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Notas : |
Article history: First published online May 12, 2023. -- Corresponding Author: Francisco A. Uzal, California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California at Davis, 105 W CVentral Ave, San Bernardino, CA 92408, USA. Email: fauzal@ucdavis.edu -- Funding: This work was supported by grant R01 AI056177 from the National Institute of Allergy and Infectious Diseases (NIAID). Research at Monash University was also supported by funding provided by the Australian Research Council to the Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics (grant no. CE0562063). -- |
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Contenido : |
ABSTRACT.- Type D enterotoxemia, caused by Clostridium perfringens epsilon toxin (ETX), is one of the most economically important clostridial diseases of sheep. Acute type D enterotoxemia is characterized by well-documented lesions in the nervous, cardiocirculatory, and pulmonary systems. However, discrepancies and confusion exist as to whether renal lesions are part of the spectrum of lesions of this condition, which is controversial considering that for many decades it has been colloquially referred to as "pulpy kidney disease". Here, the authors assess renal changes in an experimental model of acute type D enterotoxemia in sheep and evaluate the possible role of ETX in their genesis. Four groups of 6 sheep each were intraduodenally inoculated with either a wild-type virulent C. perfringens type D strain, an etx knockout mutant unable to produce ETX, the etx mutant strain complemented with the wild-type etx gene that regains the ETX toxin production, or sterile culture medium (control group). All sheep were autopsied less than 24 hours after inoculation; none of them developed gross lesions in the kidneys. Ten predefined histologic renal changes were scored in each sheep. The proportion of sheep with microscopic changes and their severity scores did not differ significantly between groups. Mild intratubular medullary hemorrhage was observed in only 2 of the 12 sheep inoculated with the wild-type or etx-complemented bacterial strains, but not in the 12 sheep of the other 2 groups. The authors conclude that no specific gross or histologic renal lesions are observed in sheep with experimental acute type D enterotoxemia. © The Author(s) 2023 MenosABSTRACT.- Type D enterotoxemia, caused by Clostridium perfringens epsilon toxin (ETX), is one of the most economically important clostridial diseases of sheep. Acute type D enterotoxemia is characterized by well-documented lesions in the nervous, cardiocirculatory, and pulmonary systems. However, discrepancies and confusion exist as to whether renal lesions are part of the spectrum of lesions of this condition, which is controversial considering that for many decades it has been colloquially referred to as "pulpy kidney disease". Here, the authors assess renal changes in an experimental model of acute type D enterotoxemia in sheep and evaluate the possible role of ETX in their genesis. Four groups of 6 sheep each were intraduodenally inoculated with either a wild-type virulent C. perfringens type D strain, an etx knockout mutant unable to produce ETX, the etx mutant strain complemented with the wild-type etx gene that regains the ETX toxin production, or sterile culture medium (control group). All sheep were autopsied less than 24 hours after inoculation; none of them developed gross lesions in the kidneys. Ten predefined histologic renal changes were scored in each sheep. The proportion of sheep with microscopic changes and their severity scores did not differ significantly between groups. Mild intratubular medullary hemorrhage was observed in only 2 of the 12 sheep inoculated with the wild-type or etx-complemented bacterial strains, but not in the 12 sheep of the other 2 ... Presentar Todo |
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Palabras claves : |
Clostridium perfringens type D; Enterotoxemia; ETX; Experimental infection; Kidneys; PLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA; Renal pathology; Sheep. |
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Asunto categoría : |
L10 Genética y mejoramiento animal |
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Marc : |
LEADER 03352naa a2200325 a 4500
001 1064216
005 2023-06-30
008 2023 bl uuuu u00u1 u #d
022 $a0300-9858 (print); 1544-2217 (online).
024 7 $a10.1177/03009858231171669$2DOI
100 1 $aGIANNITTI, F.
245 $aExperimental acute Clostridium perfringens type D enterotoxemia in sheep is not characterized by specific renal lesions.$h[electronic resource]
260 $c2023
500 $aArticle history: First published online May 12, 2023. -- Corresponding Author: Francisco A. Uzal, California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California at Davis, 105 W CVentral Ave, San Bernardino, CA 92408, USA. Email: fauzal@ucdavis.edu -- Funding: This work was supported by grant R01 AI056177 from the National Institute of Allergy and Infectious Diseases (NIAID). Research at Monash University was also supported by funding provided by the Australian Research Council to the Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics (grant no. CE0562063). --
520 $aABSTRACT.- Type D enterotoxemia, caused by Clostridium perfringens epsilon toxin (ETX), is one of the most economically important clostridial diseases of sheep. Acute type D enterotoxemia is characterized by well-documented lesions in the nervous, cardiocirculatory, and pulmonary systems. However, discrepancies and confusion exist as to whether renal lesions are part of the spectrum of lesions of this condition, which is controversial considering that for many decades it has been colloquially referred to as "pulpy kidney disease". Here, the authors assess renal changes in an experimental model of acute type D enterotoxemia in sheep and evaluate the possible role of ETX in their genesis. Four groups of 6 sheep each were intraduodenally inoculated with either a wild-type virulent C. perfringens type D strain, an etx knockout mutant unable to produce ETX, the etx mutant strain complemented with the wild-type etx gene that regains the ETX toxin production, or sterile culture medium (control group). All sheep were autopsied less than 24 hours after inoculation; none of them developed gross lesions in the kidneys. Ten predefined histologic renal changes were scored in each sheep. The proportion of sheep with microscopic changes and their severity scores did not differ significantly between groups. Mild intratubular medullary hemorrhage was observed in only 2 of the 12 sheep inoculated with the wild-type or etx-complemented bacterial strains, but not in the 12 sheep of the other 2 groups. The authors conclude that no specific gross or histologic renal lesions are observed in sheep with experimental acute type D enterotoxemia. © The Author(s) 2023
653 $aClostridium perfringens type D
653 $aEnterotoxemia
653 $aETX
653 $aExperimental infection
653 $aKidneys
653 $aPLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA
653 $aRenal pathology
653 $aSheep
700 1 $aGARCÍA, J. P.
700 1 $aADAMS, V.
700 1 $aARMENDANO, J.
700 1 $aBEINGESSER, J.
700 1 $aROOD, J.
700 1 $aUZAL, F. A.
773 $tVeterinary Pathology. 2023, vol.60(4):412-419. https://doi.org/10.1177/03009858231171669
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