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 | Acceso al texto completo restringido a Biblioteca INIA Tacuarembó. Por información adicional contacte bibliotb@tb.inia.org.uy. |
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Registro completo
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Biblioteca (s) : |
INIA Tacuarembó. |
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Fecha : |
01/09/2020 |
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Actualizado : |
01/09/2020 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
MACHADO, M.; CASTRO, M.B; GIMENO, E.J.; BARROS, S.S.; RIET-CORREA, F. |
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Afiliación : |
MIZAEL MACHADO DA COSTA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MARCIO B. CASTRO, Laboratorio de Patologia Veterinaria, Universidade de Brasília, Brasília, Brazil; EDUARDO J. GIMENO, Faculdad de Ciencias Veterinarias, National University of La Plata, Argentina; SEVERO S. BARROS, Laboratorio de Patologia Veterinaria, Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil; FRANKLIN RIET-CORREA AMARAL, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
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Título : |
Enzootic calcinosis in ruminants: A review. |
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Fecha de publicación : |
2020 |
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Fuente / Imprenta : |
Toxicon, 2020, volumen 187, Pages 1-9. Doi: https://doi.org/10.1016/j.toxicon.2020.08.009 |
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DOI : |
10.1016/j.toxicon.2020.08.009 |
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Idioma : |
Inglés |
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Contenido : |
ABSTRACT: Enzootic calcinosis (EC), is a chronic disease, caused by toxic plants, which has mainly affected ruminants for more than 100 years. It is characterized by a soft tissue calcification, hypercalcemia, hyperphosphatemia, hypoparathiroidism, hypercalcitoninism, osteonecrosis, and osteopetrosis. The toxic compound reported in some of these plants are 1,25(OH)2D3 glycosides. Characterization of calcinogenic principles were performed with Solanum glaucophyllum, Trisetum flavescens, Cestrum diurnum, and Stenotaphrum secundatum. Other plant species involved in EC are: Nierembergia rivularis, Nierembergia veitchii, Solanum torvum, and Solanum stuckertii. Clinical and pathological findings are well characterized. We present different aspects of the pathogenic mechanism of EC, including genetic modulation, expression of bone proteins, cellular de-differentiation of arterial smooth muscle cells, phenotypic changes, production of a calcifiable matrix, and modulation of the calcium and phosphorus balance. The use of comparative pathology can bring significant advances in the understanding of the pathogenic mechanism. In this review we present a broad approach to the different aspects of intoxication: history of EC on different continents; plant species, distribution and morphology; toxic principle; pathogenesis; epidemiology; clinical signs; diagnosis; and control and prophylaxis. |
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Palabras claves : |
CALCINOGENIC PLANTS; CALCINOSIS ENZOÓTICA; ENZOOTIC CALCINOSIS; INTOXICACIÓN; PATHOGENESIS; PLANTAS TÓXICAS; RUMIANTES; VITAMIN D; VITAMINA D. |
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Asunto categoría : |
L01 Ganadería |
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Marc : |
LEADER 02226naa a2200289 a 4500
001 1061290
005 2020-09-01
008 2020 bl uuuu u00u1 u #d
024 7 $a10.1016/j.toxicon.2020.08.009$2DOI
100 1 $aMACHADO, M.
245 $aEnzootic calcinosis in ruminants$bA review.$h[electronic resource]
260 $c2020
520 $aABSTRACT: Enzootic calcinosis (EC), is a chronic disease, caused by toxic plants, which has mainly affected ruminants for more than 100 years. It is characterized by a soft tissue calcification, hypercalcemia, hyperphosphatemia, hypoparathiroidism, hypercalcitoninism, osteonecrosis, and osteopetrosis. The toxic compound reported in some of these plants are 1,25(OH)2D3 glycosides. Characterization of calcinogenic principles were performed with Solanum glaucophyllum, Trisetum flavescens, Cestrum diurnum, and Stenotaphrum secundatum. Other plant species involved in EC are: Nierembergia rivularis, Nierembergia veitchii, Solanum torvum, and Solanum stuckertii. Clinical and pathological findings are well characterized. We present different aspects of the pathogenic mechanism of EC, including genetic modulation, expression of bone proteins, cellular de-differentiation of arterial smooth muscle cells, phenotypic changes, production of a calcifiable matrix, and modulation of the calcium and phosphorus balance. The use of comparative pathology can bring significant advances in the understanding of the pathogenic mechanism. In this review we present a broad approach to the different aspects of intoxication: history of EC on different continents; plant species, distribution and morphology; toxic principle; pathogenesis; epidemiology; clinical signs; diagnosis; and control and prophylaxis.
653 $aCALCINOGENIC PLANTS
653 $aCALCINOSIS ENZOÓTICA
653 $aENZOOTIC CALCINOSIS
653 $aINTOXICACIÓN
653 $aPATHOGENESIS
653 $aPLANTAS TÓXICAS
653 $aRUMIANTES
653 $aVITAMIN D
653 $aVITAMINA D
700 1 $aCASTRO, M.B
700 1 $aGIMENO, E.J.
700 1 $aBARROS, S.S.
700 1 $aRIET-CORREA, F.
773 $tToxicon, 2020, volumen 187, Pages 1-9. Doi: https://doi.org/10.1016/j.toxicon.2020.08.009
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INIA Tacuarembó (TBO) |
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Registro completo
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Biblioteca (s) : |
INIA Tacuarembó. |
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Fecha actual : |
08/09/2014 |
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Actualizado : |
30/09/2019 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Circulación / Nivel : |
Internacional - -- |
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Autor : |
MEDEROS, A.; WADDELL, L.; SÁNCHEZ, J.; KELTON, D.; PEREGRINE, A.S.; MENZIES, P.; VANLEEUWEN, J.; RAJIC, A. |
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Afiliación : |
AMERICA ESTHER MEDEROS SILVEIRA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
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Título : |
A systematic review meta analysis of primary research investigating the effect of selected alternative treatments on gastrointestinal nematodes in sheep under field conditions. |
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Fecha de publicación : |
2012 |
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Fuente / Imprenta : |
Preventive Veterinary Medicine, 2012, v. 104, p. 1-14 |
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Volumen : |
104 |
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Páginas : |
1-14 |
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DOI : |
10.1016/j.prevetmed.2011.10.012 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received 18 August 2011 //Received in revised form 27 October 2011 // Accepted 30 October 2011. |
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Contenido : |
Selected alternative treatments for preventing or controlling gastrointestinal nematodes (GIN) in sheep under field conditions were evaluated using a systematic review-meta-analysis methodology. Forty-three publications reporting 51 studies (21 controlled studies (CS) and 30 challenge studies (ChS)) and 85 unique treatment comparisons were included in the review. The alternative treatment categories were nutraceuticals (28 studies), breeding for genetic resistance (12), nutritional manipulation (6), homeopathies (2), administration of copper oxide wire particles (2), and biological control (1). Random effect meta-analyses (MA) and meta-regression were performed with the natural logarithm of the difference in means (lnMD) between the control and treatment groups, for fecal egg counts per gram of wet feces (FEC), worm counts (WC) or fecal egg counts per gram of dry matter (FECDM) as the outcome. Treatment effect estimates (lnMD) were back-transformed to their count ratios (CR), a relative measure of effect for controlled versus treated groups, for presentation of results. Significant heterogeneity was observed for both CS and ChS that evaluated nutraceuticals, genetic resistance and nutrition treatments. MA of ChS that investigated nutraceuticals resulted in a significant overall CR of 1.62 (P<0.01) and 1.64 (P<0.01) for FEC and FECDM, respectively and a marginal significant CR of 1.14 (P=0.06) for WC, all favoring the treated groups. MA of CS and ChS that investigated genetic resistance resulted in a significant overall CR of 5.89 and 15.42, respectively (P<0.01), again favoring treated groups. MA of CS that investigated homeopathies with FEC as an outcome were homogenous (I(2)=0.0%) and resulted in a non-significant pooled CR of 1.61. ChS investigating copper oxide wire particle treatments and WC as an outcome, were homogenous (I(2)=0.0%) and had a marginally significant pooled CR of 1.68 (P=0.06). Publication bias was observed for ChS with WC outcomes, indicating that small size studies reporting non-significant CR, were less likely to be published than similar studies that found a significant CR. In a meta-regression, randomization (6.2%) and study size (29.2%) were the main factors contributing to the total variation when the outcome was FEC, and none of the variables contributed to between study heterogeneity. When the outcome was WC, type of treatment was the only significant covariate, explaining 6% of the heterogeneity and 38.5% of the total variation. The methodological soundness and reporting of primary research in the selected studies were low. Our results indicate that from the studied alternative treatments, nutraceuticals and use of genetically resistant sheep might be more promising for control of GINs in sheep. MenosSelected alternative treatments for preventing or controlling gastrointestinal nematodes (GIN) in sheep under field conditions were evaluated using a systematic review-meta-analysis methodology. Forty-three publications reporting 51 studies (21 controlled studies (CS) and 30 challenge studies (ChS)) and 85 unique treatment comparisons were included in the review. The alternative treatment categories were nutraceuticals (28 studies), breeding for genetic resistance (12), nutritional manipulation (6), homeopathies (2), administration of copper oxide wire particles (2), and biological control (1). Random effect meta-analyses (MA) and meta-regression were performed with the natural logarithm of the difference in means (lnMD) between the control and treatment groups, for fecal egg counts per gram of wet feces (FEC), worm counts (WC) or fecal egg counts per gram of dry matter (FECDM) as the outcome. Treatment effect estimates (lnMD) were back-transformed to their count ratios (CR), a relative measure of effect for controlled versus treated groups, for presentation of results. Significant heterogeneity was observed for both CS and ChS that evaluated nutraceuticals, genetic resistance and nutrition treatments. MA of ChS that investigated nutraceuticals resulted in a significant overall CR of 1.62 (P<0.01) and 1.64 (P<0.01) for FEC and FECDM, respectively and a marginal significant CR of 1.14 (P=0.06) for WC, all favoring the treated groups. MA of CS and ChS that investigated genetic... Presentar Todo |
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Palabras claves : |
ALTERNATIVE TREATMENTS; CONTROL METHODS; GASTROINTESTINAL NEMATODES; MEDICINA VETERINARIA; META-ANALYSIS; SHEEP; SYSTEMATIC REVIEW. |
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Thesagro : |
OVINOS. |
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Asunto categoría : |
L73 Enfermedades de los animales |
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Marc : |
LEADER 03914naa a2200349 a 4500
001 1050042
005 2019-09-30
008 2012 bl uuuu u00u1 u #d
024 7 $a10.1016/j.prevetmed.2011.10.012$2DOI
100 1 $aMEDEROS, A.
245 $aA systematic review meta analysis of primary research investigating the effect of selected alternative treatments on gastrointestinal nematodes in sheep under field conditions.
260 $c2012
300 $a1-14 104
490 $v104
500 $aArticle history: Received 18 August 2011 //Received in revised form 27 October 2011 // Accepted 30 October 2011.
520 $aSelected alternative treatments for preventing or controlling gastrointestinal nematodes (GIN) in sheep under field conditions were evaluated using a systematic review-meta-analysis methodology. Forty-three publications reporting 51 studies (21 controlled studies (CS) and 30 challenge studies (ChS)) and 85 unique treatment comparisons were included in the review. The alternative treatment categories were nutraceuticals (28 studies), breeding for genetic resistance (12), nutritional manipulation (6), homeopathies (2), administration of copper oxide wire particles (2), and biological control (1). Random effect meta-analyses (MA) and meta-regression were performed with the natural logarithm of the difference in means (lnMD) between the control and treatment groups, for fecal egg counts per gram of wet feces (FEC), worm counts (WC) or fecal egg counts per gram of dry matter (FECDM) as the outcome. Treatment effect estimates (lnMD) were back-transformed to their count ratios (CR), a relative measure of effect for controlled versus treated groups, for presentation of results. Significant heterogeneity was observed for both CS and ChS that evaluated nutraceuticals, genetic resistance and nutrition treatments. MA of ChS that investigated nutraceuticals resulted in a significant overall CR of 1.62 (P<0.01) and 1.64 (P<0.01) for FEC and FECDM, respectively and a marginal significant CR of 1.14 (P=0.06) for WC, all favoring the treated groups. MA of CS and ChS that investigated genetic resistance resulted in a significant overall CR of 5.89 and 15.42, respectively (P<0.01), again favoring treated groups. MA of CS that investigated homeopathies with FEC as an outcome were homogenous (I(2)=0.0%) and resulted in a non-significant pooled CR of 1.61. ChS investigating copper oxide wire particle treatments and WC as an outcome, were homogenous (I(2)=0.0%) and had a marginally significant pooled CR of 1.68 (P=0.06). Publication bias was observed for ChS with WC outcomes, indicating that small size studies reporting non-significant CR, were less likely to be published than similar studies that found a significant CR. In a meta-regression, randomization (6.2%) and study size (29.2%) were the main factors contributing to the total variation when the outcome was FEC, and none of the variables contributed to between study heterogeneity. When the outcome was WC, type of treatment was the only significant covariate, explaining 6% of the heterogeneity and 38.5% of the total variation. The methodological soundness and reporting of primary research in the selected studies were low. Our results indicate that from the studied alternative treatments, nutraceuticals and use of genetically resistant sheep might be more promising for control of GINs in sheep.
650 $aOVINOS
653 $aALTERNATIVE TREATMENTS
653 $aCONTROL METHODS
653 $aGASTROINTESTINAL NEMATODES
653 $aMEDICINA VETERINARIA
653 $aMETA-ANALYSIS
653 $aSHEEP
653 $aSYSTEMATIC REVIEW
700 1 $aWADDELL, L.
700 1 $aSÁNCHEZ, J.
700 1 $aKELTON, D.
700 1 $aPEREGRINE, A.S.
700 1 $aMENZIES, P.
700 1 $aVANLEEUWEN, J.
700 1 $aRAJIC, A.
773 $tPreventive Veterinary Medicine, 2012$gv. 104, p. 1-14
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