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| 1. |  | CABRERA, A.; PITA, S.; GONZÁLEZ, T.; VIERA, A.; VERGER, L.; PIEGAS, S.; WILLAT, G.; FRESIA, P.; BASMADJIÁN, Y. Genetic variability highlights the invasion route of the Lutzomyia longipalpis complex, the main vector of Visceral Leishmaniasis in Uruguay. Zoonoses and Public Health. 2023, Volume 70, Issue 5, Pages 383-392. doi: https://doi.org/10.1111/zph.13036 Article history: First published 10 March 2023. -- Correspondence author: Andrés, C.; Departamento de Parasitología y Micología, Instituto de Higiene, Facultad de Medicina, UdelaR, Montevideo, Uruguay; email:andresmcc1@gmail.com --...| Biblioteca(s): INIA Las Brujas. |
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 | Acceso al texto completo restringido a Biblioteca INIA Las Brujas. Por información adicional contacte bibliolb@inia.org.uy. |
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha actual : |
19/04/2023 |
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Actualizado : |
14/09/2023 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Circulación / Nivel : |
Internacional - -- |
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Autor : |
CABRERA, A.; PITA, S.; GONZÁLEZ, T.; VIERA, A.; VERGER, L.; PIEGAS, S.; WILLAT, G.; FRESIA, P.; BASMADJIÁN, Y. |
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Afiliación : |
ANDRÉS CABRERA, Dpto. Parasitología y Micología, Inst.Higiene, Fac. Medicina, UdelaR, Mdeo, Uruguay; Lab. Interacciones Hospedero-Patógeno, Inst.Pasteur Mdeo, Mdeo, Uruguay; Unid. Microbiología, Dpto. Patobiología, Fac. Veterinaria, UdelaR, Mdeo, Uruguay.; SEBASTIÁN PITA, Laboratorio de Interacciones Hospedero-Patógeno, Institut Pasteur Montevideo, Montevideo, Uruguay Sección Genética Evolutiva, Facultad de Ciencias, UdelaR, Montevideo, Uruguay; TELMA GONZÁLEZ, Departamento de Parasitología y Micología, Instituto de Higiene, Facultad de Medicina, UdelaR, Montevideo, Uruguay; ANA VIERA, Departamento de Parasitología y Micología, Instituto de Higiene, Facultad de Medicina, UdelaR, Montevideo, Uruguay; LORENZO VERGER, Ministerio de Salud Pública, Uruguay, Montevideo, Uruguay; SOFÍA PIEGAS, Ministerio de Salud Pública, Uruguay, Montevideo, Uruguay; GABRIELA WILLAT, Ministerio de Salud Pública, Uruguay, Montevideo, Uruguay; PABLO FRESIA, Unidad Mixta UMPI, Institut Pasteur Montevideo + INIA, Montevideo, Uruguay; YESTER BASMADJIÁN, Departamento de Parasitología y Micología, Instituto de Higiene, Facultad de Medicina, UdelaR, Montevideo, Uruguay. |
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Título : |
Genetic variability highlights the invasion route of the Lutzomyia longipalpis complex, the main vector of Visceral Leishmaniasis in Uruguay. |
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Fecha de publicación : |
2023 |
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Fuente / Imprenta : |
Zoonoses and Public Health. 2023, Volume 70, Issue 5, Pages 383-392. doi: https://doi.org/10.1111/zph.13036 |
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ISSN : |
1863-1959 |
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DOI : |
10.1111/zph.13036 |
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Idioma : |
Inglés |
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Notas : |
Article history: First published 10 March 2023. -- Correspondence author: Andrés, C.; Departamento de Parasitología y Micología, Instituto de Higiene, Facultad de Medicina, UdelaR, Montevideo, Uruguay; email:andresmcc1@gmail.com -- Publisher: John Wiley and Sons Inc. -- Supplementary material available. -- |
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Contenido : |
In the Americas, the sandfly Lutzomyia longipalpis is the main vector of the parasitic protozoa Leishmania infantum, the etiological agent of visceral leishmaniasis (VL). The Lu. longipalpis species complex is currently discontinuously distributed across the Neotropical region, from Mexico to the north of Argentina and Uruguay. During its continental spreading, it must have adapted to several biomes and temperature amplitudes, when founder events should have contributed to the high genetic divergence and geographical structure currently observed, reinforcing the speciation process. The first report of Lu. longipalpis in Uruguay was in 2010, calling the attention of Public Health authorities. Five years later, the parasite Le. infantum was recorded and in 2015 the first case of VL in canids was reported. Hitherto seven human deaths by VL have been reported in Uruguay. Here, we publish the first DNA sequences from the mitochondrial genes ND4 and CYTB of Lu. longipalpis collected in Uruguay, and we used these molecular markers to investigate their genetic variability and population structure. We described four new ND4 haplotypes in a total of 98 (4/98) and one CYTB in a total of 77 (1/77). As expected, we were able to establish that the Lu. longipalpis collected in two localities (i.e. Salto and Bella Unión) from the north of Uruguay are closely related to the populations from neighbouring countries. We also propose that the possible route for the vector arrival to the region may have been through vegetation and forest corridors of the Uruguay River system, as well as it may have benefited from landscape modifications generated by commercial forestation. The ecological-scale processes shaping Lu. longipalpis populations, the identification of genetically homogeneous groups and the gene flow among them must be carefully investigated by using highly sensible molecular markers (i.e. genome wide SNPs) since it will help to the understanding of VL transmission and contribute to the planification of public policies on its control. © 2023 Wiley-VCH GmbH. Published by John Wiley & Sons Ltd. MenosIn the Americas, the sandfly Lutzomyia longipalpis is the main vector of the parasitic protozoa Leishmania infantum, the etiological agent of visceral leishmaniasis (VL). The Lu. longipalpis species complex is currently discontinuously distributed across the Neotropical region, from Mexico to the north of Argentina and Uruguay. During its continental spreading, it must have adapted to several biomes and temperature amplitudes, when founder events should have contributed to the high genetic divergence and geographical structure currently observed, reinforcing the speciation process. The first report of Lu. longipalpis in Uruguay was in 2010, calling the attention of Public Health authorities. Five years later, the parasite Le. infantum was recorded and in 2015 the first case of VL in canids was reported. Hitherto seven human deaths by VL have been reported in Uruguay. Here, we publish the first DNA sequences from the mitochondrial genes ND4 and CYTB of Lu. longipalpis collected in Uruguay, and we used these molecular markers to investigate their genetic variability and population structure. We described four new ND4 haplotypes in a total of 98 (4/98) and one CYTB in a total of 77 (1/77). As expected, we were able to establish that the Lu. longipalpis collected in two localities (i.e. Salto and Bella Unión) from the north of Uruguay are closely related to the populations from neighbouring countries. We also propose that the possible route for the vector arrival to the region m... Presentar Todo |
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Palabras claves : |
Infectious disease; Life on land (SDS Goal 15); Lutzomyia longipalpis complex; Molecular markers; MtDNA; Phylogeography; UNIDAD MIXTA PASTEUR + INIA. |
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Asunto categoría : |
A50 Investigación agraria |
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Marc : |
LEADER 03480naa a2200337 a 4500
001 1064042
005 2023-09-14
008 2023 bl uuuu u00u1 u #d
022 $a1863-1959
024 7 $a10.1111/zph.13036$2DOI
100 1 $aCABRERA, A.
245 $aGenetic variability highlights the invasion route of the Lutzomyia longipalpis complex, the main vector of Visceral Leishmaniasis in Uruguay.$h[electronic resource]
260 $c2023
500 $aArticle history: First published 10 March 2023. -- Correspondence author: Andrés, C.; Departamento de Parasitología y Micología, Instituto de Higiene, Facultad de Medicina, UdelaR, Montevideo, Uruguay; email:andresmcc1@gmail.com -- Publisher: John Wiley and Sons Inc. -- Supplementary material available. --
520 $aIn the Americas, the sandfly Lutzomyia longipalpis is the main vector of the parasitic protozoa Leishmania infantum, the etiological agent of visceral leishmaniasis (VL). The Lu. longipalpis species complex is currently discontinuously distributed across the Neotropical region, from Mexico to the north of Argentina and Uruguay. During its continental spreading, it must have adapted to several biomes and temperature amplitudes, when founder events should have contributed to the high genetic divergence and geographical structure currently observed, reinforcing the speciation process. The first report of Lu. longipalpis in Uruguay was in 2010, calling the attention of Public Health authorities. Five years later, the parasite Le. infantum was recorded and in 2015 the first case of VL in canids was reported. Hitherto seven human deaths by VL have been reported in Uruguay. Here, we publish the first DNA sequences from the mitochondrial genes ND4 and CYTB of Lu. longipalpis collected in Uruguay, and we used these molecular markers to investigate their genetic variability and population structure. We described four new ND4 haplotypes in a total of 98 (4/98) and one CYTB in a total of 77 (1/77). As expected, we were able to establish that the Lu. longipalpis collected in two localities (i.e. Salto and Bella Unión) from the north of Uruguay are closely related to the populations from neighbouring countries. We also propose that the possible route for the vector arrival to the region may have been through vegetation and forest corridors of the Uruguay River system, as well as it may have benefited from landscape modifications generated by commercial forestation. The ecological-scale processes shaping Lu. longipalpis populations, the identification of genetically homogeneous groups and the gene flow among them must be carefully investigated by using highly sensible molecular markers (i.e. genome wide SNPs) since it will help to the understanding of VL transmission and contribute to the planification of public policies on its control. © 2023 Wiley-VCH GmbH. Published by John Wiley & Sons Ltd.
653 $aInfectious disease
653 $aLife on land (SDS Goal 15)
653 $aLutzomyia longipalpis complex
653 $aMolecular markers
653 $aMtDNA
653 $aPhylogeography
653 $aUNIDAD MIXTA PASTEUR + INIA
700 1 $aPITA, S.
700 1 $aGONZÁLEZ, T.
700 1 $aVIERA, A.
700 1 $aVERGER, L.
700 1 $aPIEGAS, S.
700 1 $aWILLAT, G.
700 1 $aFRESIA, P.
700 1 $aBASMADJIÁN, Y.
773 $tZoonoses and Public Health. 2023, Volume 70, Issue 5, Pages 383-392. doi: https://doi.org/10.1111/zph.13036
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