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| 1. |  | SPERONI, G.; MAZZELLA, C.; PRITSCH, C.; BONIFACINO, M.; VAIO, M.; SOUZA-PÉREZ, M.; VÁSQUEZ, S.; DA LUZ, C.; TRUJILLO, C.; NÚÑEZ, E.; GONZÁLEZ, M.; ASTIGARRAGA, L.; MACHADO, G.; BORGES, A.; VIGNALE, B.; CABRERA, D. Cuánto conocemos del arazá en Uruguay y sus poblaciones silvestres? In: INIA (INSTITUTO NACIONAL DE INVESTIGACIÓN AGROPECUARIA); PROGRAMA NACIONAL PRODUCCIÓN FRUTÍCOLA. 8° Encuentro Nacional sobre Frutos Nativos. Las Brujas, Canelones (Uruguay): INIA, 2017. p. 6-12 (Actividades de Difusión; 772)| Biblioteca(s): INIA Las Brujas. |
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 | Acceso al texto completo restringido a Biblioteca INIA Las Brujas. Por información adicional contacte bibliolb@inia.org.uy. |
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha actual : |
21/10/2024 |
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Actualizado : |
21/10/2024 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Circulación / Nivel : |
Internacional - -- |
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Autor : |
LOZANO, J.; FABIUS, S.; FERNÁNDEZ-CIGANDA, S.; URBANAVICIUS, J.; PICCINI, C.; SCORZA, C.; ZUNINO, Z. |
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Afiliación : |
J. LOZANO, Department of Microbiology, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay; S. FABIUS, Department of Experimental Neuropharmacology, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay; SOFÍA FERNÁNDEZ-CIGANDA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; Department of Microbiology, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay; J. URBANAVICIUS, Department of Experimental Neuropharmacology, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay; C. PICCINI, Department of Microbiology, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay; C. SCORZA, Department of Experimental Neuropharmacology, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay; P. ZUNINO, Department of Microbiology, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay. |
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Título : |
Beneficial effect of GABA-producing Lactiplantibacillus strain LPB145 isolated from cheese starters evaluated in anxiety- and depression-like
behaviours in rats. |
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Complemento del título : |
Research article. |
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Fecha de publicación : |
2024 |
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Fuente / Imprenta : |
Beneficial Microbes, 2024, Volume 15, Issue 5, Pages 465-479. https://doi.org/10.1163/18762891-bja00024 |
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ISSN : |
1876-2891 (online) |
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DOI : |
10.1163/18762891-bja00024 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received 21 October 2023, Accepted 19 June 2024, Published online 4 July 2024. -- Correspondence: Zunino, P.; Department of Microbiology, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay; email:pmzunino@gmail.com -- Published with license by Koninklijke Brill BV. |
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Contenido : |
ABSTRACT.- In a previous study, we reported the in vitro potential probiotic and gamma-aminobutyric acid (GABA) production, of several strains from a collection of Lactiplantibacillus (Lpb) strains within the community of natural whey starters from the artisanal cheese industry. GABA is a non-protein amino acid widely distributed in nature and produced in animals, plants, and microorganisms. However, the best known role of GABA is its function as the major inhibitory neurotransmitter of the central nervous system. Preclinical and clinical evidence suggests that the GABAergic system has a relevant role in mental health disorders, such as anxiety and major depression. The modulation of the GABAergic system has been suggested as a potential strategy for treatment, one such mechanism of modulation is the influence of the microbiota-gut-brain axis through probiotic treatments. The present study was designed to investigate the in vivo probiotic potential of LPB145, a Lactiplantibacillus strain previously characterised as a GABA-producing potentially probiotic strain. Therefore, we evaluated the behavioural effects of chronic oral administration of LPB145 on rats' anxiety- and depression-like behaviours, using the elevated plus maze, open field, and the forced swimming test. The impact of LPB145 strain treatment on the gut microbiota structure and diversity was assessed to discern a possible mechanism of action of the LPB145 treatment through the microbiota-gut-brain axis. Our results showed that LPB145 administration induced an antidepressive-like behaviour without changes in locomotor activity. In contrast, the treatment did not modify the experimental anxiety. The structure and diversity of the intestinal microbiota remained unaffected by the treatment when compared to the control. However, specific clades that could be implicated in the behavioural changes did show differences in their relative abundance. These findings provide evidence regarding the potential of probiotic strains isolated from alimentary sources, to modulate the microbiota-gut-brain axis and positively impact mental health. © J. LOZANO et al., 2024. MenosABSTRACT.- In a previous study, we reported the in vitro potential probiotic and gamma-aminobutyric acid (GABA) production, of several strains from a collection of Lactiplantibacillus (Lpb) strains within the community of natural whey starters from the artisanal cheese industry. GABA is a non-protein amino acid widely distributed in nature and produced in animals, plants, and microorganisms. However, the best known role of GABA is its function as the major inhibitory neurotransmitter of the central nervous system. Preclinical and clinical evidence suggests that the GABAergic system has a relevant role in mental health disorders, such as anxiety and major depression. The modulation of the GABAergic system has been suggested as a potential strategy for treatment, one such mechanism of modulation is the influence of the microbiota-gut-brain axis through probiotic treatments. The present study was designed to investigate the in vivo probiotic potential of LPB145, a Lactiplantibacillus strain previously characterised as a GABA-producing potentially probiotic strain. Therefore, we evaluated the behavioural effects of chronic oral administration of LPB145 on rats' anxiety- and depression-like behaviours, using the elevated plus maze, open field, and the forced swimming test. The impact of LPB145 strain treatment on the gut microbiota structure and diversity was assessed to discern a possible mechanism of action of the LPB145 treatment through the microbiota-gut-brain axis. Our resu... Presentar Todo |
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Palabras claves : |
Depression; Gamma-aminobutyric acid; Intestinal microbiota; MGB axis; Natural whey starter; PLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA; Probiotic; Rats. |
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Asunto categoría : |
A50 Investigación agraria |
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Marc : |
LEADER 03533naa a2200325 a 4500
001 1064885
005 2024-10-21
008 2024 bl uuuu u00u1 u #d
022 $a1876-2891 (online)
024 7 $a10.1163/18762891-bja00024$2DOI
100 1 $aLOZANO, J.
245 $aBeneficial effect of GABA-producing Lactiplantibacillus strain LPB145 isolated from cheese starters evaluated in anxiety- and depression-like behaviours in rats.$h[electronic resource]
260 $c2024
500 $aArticle history: Received 21 October 2023, Accepted 19 June 2024, Published online 4 July 2024. -- Correspondence: Zunino, P.; Department of Microbiology, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay; email:pmzunino@gmail.com -- Published with license by Koninklijke Brill BV.
520 $aABSTRACT.- In a previous study, we reported the in vitro potential probiotic and gamma-aminobutyric acid (GABA) production, of several strains from a collection of Lactiplantibacillus (Lpb) strains within the community of natural whey starters from the artisanal cheese industry. GABA is a non-protein amino acid widely distributed in nature and produced in animals, plants, and microorganisms. However, the best known role of GABA is its function as the major inhibitory neurotransmitter of the central nervous system. Preclinical and clinical evidence suggests that the GABAergic system has a relevant role in mental health disorders, such as anxiety and major depression. The modulation of the GABAergic system has been suggested as a potential strategy for treatment, one such mechanism of modulation is the influence of the microbiota-gut-brain axis through probiotic treatments. The present study was designed to investigate the in vivo probiotic potential of LPB145, a Lactiplantibacillus strain previously characterised as a GABA-producing potentially probiotic strain. Therefore, we evaluated the behavioural effects of chronic oral administration of LPB145 on rats' anxiety- and depression-like behaviours, using the elevated plus maze, open field, and the forced swimming test. The impact of LPB145 strain treatment on the gut microbiota structure and diversity was assessed to discern a possible mechanism of action of the LPB145 treatment through the microbiota-gut-brain axis. Our results showed that LPB145 administration induced an antidepressive-like behaviour without changes in locomotor activity. In contrast, the treatment did not modify the experimental anxiety. The structure and diversity of the intestinal microbiota remained unaffected by the treatment when compared to the control. However, specific clades that could be implicated in the behavioural changes did show differences in their relative abundance. These findings provide evidence regarding the potential of probiotic strains isolated from alimentary sources, to modulate the microbiota-gut-brain axis and positively impact mental health. © J. LOZANO et al., 2024.
653 $aDepression
653 $aGamma-aminobutyric acid
653 $aIntestinal microbiota
653 $aMGB axis
653 $aNatural whey starter
653 $aPLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA
653 $aProbiotic
653 $aRats
700 1 $aFABIUS, S.
700 1 $aFERNÁNDEZ-CIGANDA, S.
700 1 $aURBANAVICIUS, J.
700 1 $aPICCINI, C.
700 1 $aSCORZA, C.
700 1 $aZUNINO, Z.
773 $tBeneficial Microbes, 2024, Volume 15, Issue 5, Pages 465-479. https://doi.org/10.1163/18762891-bja00024
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