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| Registros recuperados : 4 | |
| Registros recuperados : 4 | |
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 | Acceso al texto completo restringido a Biblioteca INIA Las Brujas. Por información adicional contacte bibliolb@inia.org.uy. |
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha actual : |
11/09/2014 |
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Actualizado : |
24/06/2021 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Circulación / Nivel : |
A - 1 |
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Autor : |
SOUZA, A.L.A.; DÍAZ DELLAVALLE, P.; CABRERA, A.; LARRAÑAGA, P.; DALLA RIZZA, M.; DE-SIMONE, S.G. |
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Afiliación : |
PAOLA ALEXANDRA DIAZ DELLAVALLE, Instituto Nacional de Investigación Agropecuaria (INIA), Uruguay; ANDREA CECILIA CABRERA BARRIOS, Instituto Nacional de Investigación Agropecuaria (INIA), Uruguay; MARCO DALLA RIZZA VILARO, Instituto Nacional de Investigación Agropecuaria (INIA), Uruguay. |
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Título : |
Antimicrobial activity of pleurocidin is retained in Plc-2, a C-terminal 12-amino acid fragment. |
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Fecha de publicación : |
2013 |
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Fuente / Imprenta : |
Peptides, 2013, v.45, p.78-84. |
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ISSN : |
0196-9781 |
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DOI : |
10.1016/j.peptides.2013.03.030 |
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Idioma : |
Inglés |
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Contenido : |
ABSTRACT.
An analysis of a series of five peptides composed of various portions of the pleurocidin (Plc) sequence identified a l2-amino acid fragment from the C-terminus of Plc, designated Plc-2, as the smallest fragment that retained a antimicrobial activity comparable to that of the parent compound. MIC tests in vitro with low-ionic-strength medium showed that Plc-2 has potent activity against Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus but not against Enterococcus faecalis. The antifungal activity of the synthetic peptides against phytopathogenic fungi, such as Fusarium oxysporum, Colletotrichum sp., Aspergillus niger and Alternaria sp., also identified Plc-2 as a biologically active peptide. Microscopy studies of fluorescently stained fungi treated with Plc-2 demonstrated that cytoplasmic and nuclear membranes were compromised in all strains of phytopathogenic fungi tested. Together, these results identify Plc-2 as a potential antimicrobial agent with similar properties to its parent compound, pleurocidin. In addition, it demonstrated that the KHVGKAALTHYL residues are critical for the antimicrobial activity described for pleurocidin.
© 2013 Elsevier Inc. All rights reserved. |
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Thesagro : |
ALTERNARIA; HONGOS; PÉPTIDOS. |
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Asunto categoría : |
H01 Protección de plantas - Aspectos generales |
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Marc : |
LEADER 01911naa a2200241 a 4500
001 1050151
005 2021-06-24
008 2013 bl uuuu u00u1 u #d
022 $a0196-9781
024 7 $a10.1016/j.peptides.2013.03.030$2DOI
100 1 $aSOUZA, A.L.A.
245 $aAntimicrobial activity of pleurocidin is retained in Plc-2, a C-terminal 12-amino acid fragment.$h[electronic resource]
260 $c2013
520 $aABSTRACT. An analysis of a series of five peptides composed of various portions of the pleurocidin (Plc) sequence identified a l2-amino acid fragment from the C-terminus of Plc, designated Plc-2, as the smallest fragment that retained a antimicrobial activity comparable to that of the parent compound. MIC tests in vitro with low-ionic-strength medium showed that Plc-2 has potent activity against Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus but not against Enterococcus faecalis. The antifungal activity of the synthetic peptides against phytopathogenic fungi, such as Fusarium oxysporum, Colletotrichum sp., Aspergillus niger and Alternaria sp., also identified Plc-2 as a biologically active peptide. Microscopy studies of fluorescently stained fungi treated with Plc-2 demonstrated that cytoplasmic and nuclear membranes were compromised in all strains of phytopathogenic fungi tested. Together, these results identify Plc-2 as a potential antimicrobial agent with similar properties to its parent compound, pleurocidin. In addition, it demonstrated that the KHVGKAALTHYL residues are critical for the antimicrobial activity described for pleurocidin. © 2013 Elsevier Inc. All rights reserved.
650 $aALTERNARIA
650 $aHONGOS
650 $aPÉPTIDOS
700 1 $aDÍAZ DELLAVALLE, P.
700 1 $aCABRERA, A.
700 1 $aLARRAÑAGA, P.
700 1 $aDALLA RIZZA, M.
700 1 $aDE-SIMONE, S.G.
773 $tPeptides, 2013$gv.45, p.78-84.
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INIA Las Brujas (LB) |
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