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 | Acceso al texto completo restringido a Biblioteca INIA Las Brujas. Por información adicional contacte bibliolb@inia.org.uy. |
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha actual : |
06/10/2014 |
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Actualizado : |
10/02/2020 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Circulación / Nivel : |
A - 2 |
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Autor : |
SIMEONE, R.; MISZTAL, I.; AGUILAR, I.; LEGARRA, A. |
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Afiliación : |
IGNACIO AGUILAR GARCIA, Instituto Nacional de Investigación Agropecuaria (INIA), Uruguay. |
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Título : |
Evaluation of the utility of diagonal elements of the genomic relationship matrix as a diagnostic tool to detect mislabelled genotyped animals in a broiler chicken population. |
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Fecha de publicación : |
2011 |
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Fuente / Imprenta : |
Journal of Animal Breeding and Genetics, 2011, v.128, no.5, p.386-393. |
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ISSN : |
0931-2668 |
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DOI : |
http://dx.doi.org/10.1111/j.1439-0388.2011.00926.x |
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Idioma : |
Inglés |
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Contenido : |
ABSTRACT,
This study explored distributions of diagonal elements of genomic relationship matrix (G), evaluated the utility of G as a diagnostic tool to detect mislabelled animals in a genomic dataset and evaluated the effect of mislabelled animals on the accuracy of genomic evaluation. Populations of 10000 animals were simulated with 60000 SNP varying in allele frequency at each locus between 0.02 and 0.98. Diagonal elements of G were distributed with a single peak (mean=1.00±0.03) and ranged from 0.84 through 1.36. Mixed populations were also simulated: 7000 animals with frequencies of second alleles ranging from 0.02 through 0.98 were combined with 1750 or 7000 animals with frequencies of second alleles ranging from 0.0 through 1.0. The resulting distributions of diagonal elements of G were bimodal. Body weight at 6weeks was provided by Cobb-Vantress for broiler chickens, of which 3285 were genotyped for 57636 SNP. Analysis used a combined genomic and pedigree relationship matrix; G was scaled using current allele frequencies. The distribution of diagonal elements was multimodal and ranged from 0.54 to 3.23. Animals with diagonal elements >1.5 were identified as coming from another chicken line or as having low call rates. Removal of mislabelled animals increased accuracy by 0.01. For the studied type of population, diagonal elements of G may be a useful tool to help identify mislabelled animals or secondary populations.
© 2011 Blackwell Verlag GmbH. |
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Thesagro : |
GENOTIPOS; MEJORAMIENTO GENÉTICO ANIMAL; MODELOS DE SIMULACIÓN; POLLO; SELECCIÓN DE GENOTIPOS. |
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Asunto categoría : |
L10 Genética y mejoramiento animal |
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Marc : |
LEADER 02325naa a2200241 a 4500
001 1050930
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008 2011 bl uuuu u00u1 u #d
022 $a0931-2668
024 7 $ahttp://dx.doi.org/10.1111/j.1439-0388.2011.00926.x$2DOI
100 1 $aSIMEONE, R.
245 $aEvaluation of the utility of diagonal elements of the genomic relationship matrix as a diagnostic tool to detect mislabelled genotyped animals in a broiler chicken population.$h[electronic resource]
260 $c2011
520 $aABSTRACT, This study explored distributions of diagonal elements of genomic relationship matrix (G), evaluated the utility of G as a diagnostic tool to detect mislabelled animals in a genomic dataset and evaluated the effect of mislabelled animals on the accuracy of genomic evaluation. Populations of 10000 animals were simulated with 60000 SNP varying in allele frequency at each locus between 0.02 and 0.98. Diagonal elements of G were distributed with a single peak (mean=1.00±0.03) and ranged from 0.84 through 1.36. Mixed populations were also simulated: 7000 animals with frequencies of second alleles ranging from 0.02 through 0.98 were combined with 1750 or 7000 animals with frequencies of second alleles ranging from 0.0 through 1.0. The resulting distributions of diagonal elements of G were bimodal. Body weight at 6weeks was provided by Cobb-Vantress for broiler chickens, of which 3285 were genotyped for 57636 SNP. Analysis used a combined genomic and pedigree relationship matrix; G was scaled using current allele frequencies. The distribution of diagonal elements was multimodal and ranged from 0.54 to 3.23. Animals with diagonal elements >1.5 were identified as coming from another chicken line or as having low call rates. Removal of mislabelled animals increased accuracy by 0.01. For the studied type of population, diagonal elements of G may be a useful tool to help identify mislabelled animals or secondary populations. © 2011 Blackwell Verlag GmbH.
650 $aGENOTIPOS
650 $aMEJORAMIENTO GENÉTICO ANIMAL
650 $aMODELOS DE SIMULACIÓN
650 $aPOLLO
650 $aSELECCIÓN DE GENOTIPOS
700 1 $aMISZTAL, I.
700 1 $aAGUILAR, I.
700 1 $aLEGARRA, A.
773 $tJournal of Animal Breeding and Genetics, 2011$gv.128, no.5, p.386-393.
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