01940naa a2200313 a 450000100080000000500110000800800410001902200140006002400390007410000160011324501290012926000090025850003860026752006150065365300200126865300190128865300140130765300230132165300490134465300210139370000210141470000150143570000160145070000140146670000150148070000180149570000200151377300930153310640632023-05-02       2023    bl uuuu     u00u1 u    #d  a0041-01017 a10.1016/j.toxicon.2023.1071242DOI1 aMACHADO, M.  aLantana camara poisoning in cattle that took refuge during a storm in a forest invaded by this plant.h[electronic resource]  c2023  aArticle history: Received 8 March 2023; Received in revised form 7 April 2023; Accepted 10 April 2023; Available online 11 April 2023. -- Corresponding author: Riet-Correa, F.; Instituto Nacional de Investigación Agropecuaria, Plataforma de Salud Animal, Estación Experimental del Norte, Tacuarembó, Uruguay, email:franklinrietcorrea@gmail.com  -- Handling Editor: Ray Norton --  aAn outbreak of poisoning by Lantana camara occurred in cattle when a herd sought refuge in a Eucalyptus forest heavily infested by this plant. The animals showed apathy, elevated serum activities of hepatic enzymes, severe photosensitivity, jaundice, hepatomegaly and nephrosis. After a clinical manifestation period of 2-15 days, 74 out of 170 heifers died. The main histological changes were random hepatocellular necrosis, cholestasis, biliary proliferation and, in one animal, centrilobular necrosis. Immunostaining for Caspase 3 detected scattered apoptotic hepatocytes. © 2023 Published by Elsevier Ltd.  aHepatic lesions  aLantana camara  aNephrosis  aPhotosensitization  aPLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL  aPoisonous plants1 aOLIVEIRA, L.G.S.1 aSCHILD, C.1 aBOABAID, F.1 aLUCAS, M.1 aBURONI, F.1 aCASTRO, M. B.1 aRIET-CORREA, F.  tToxicon, 2023, Volume 229, article 107124. https://doi.org/10.1016/j.toxicon.2023.107124