02089naa a2200313 a 450000100080000000500110000800800410001902200140006002400390007410000160011324501060012926000090023550003770024452007370062165300240135865300250138265300270140765300560143465300210149065300240151170000180153570000230155370000300157670000170160670000250162370000200164870000170166877300900168510646462024-06-13       2024    bl uuuu     u00u1 u    #d  a0041-01017 a10.1016/j.toxicon.2024.1077802DOI1 aMACHADO, M.  aBilateral stringhalt associated with Hypochaeris radicata in uruguayan horses.h[electronic resource]  c2024  aArticle history: Received 20 April 2024, Revised 25 May 2024, Accepted 28 May 2024, Available online 29 May 2024, Version of Record 31 May 2024. -- Corresponding author: Mizael Machado; Plataforma de Investigación en Salud Animal (PSA), Instituto Nacional de Investigación Agropecuaria (INIA), Estación Exprerimental Tacuarembó, Uruguay; email:mmachado@inia.org.uy  --  aABSTRACT.- We reported thirteen cases of bilateral stringhalt associated with Hypochaeris radicata that occurred in horses in Uruguay during a severe drought in the summer of 2023. All horses were affected chronically and progressively by bilateral hyperflexion of hindlimbs. In two severely affected horses, the main histological lesions included neuronal chromatolysis and axonal spheroids in the ventral gray horn in the lumbar and sacral spinal cord and axonal degeneration and digestion chambers in ventral roots fibers and long peripheral nerves. We suggest that in addition to injuries to peripheral nerves, lesions in the spinal cord play an important role in the clinical signs of stringhalt in horses. © 2024 Elsevier Ltd  aAxonal degeneration  aHypochaeris radicata  aNeuronal chromatolysis  aPLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA  aPoisonous plants  aSpinal cord lesions1 aCAMACHO, A.L.1 aCOUBROUGH, CHARLES1 aR. R. QUEIROZ-MACHADO, C.1 aCUSTODIO, C.1 aBARROS, CLAUDIO S.L.1 aRIET-CORREA, F.1 aMENCHACA, A.  tToxicon, July 2024, Volume 245, 107780. https://doi.org/10.1016/j.toxicon.2024.107780