02223naa a2200313 a 450000100080000000500110000800800410001902200140006002400330007410000170010724500860012426000090021050005090021952008190072865300290154765300180157665300220159465300090161665300140162565300350163965300270167470000230170170000220172470000160174670000140176270000190177670000210179577300930181610649672024-12-02       2024    bl uuuu     u00u1 u    #d  a1364-727X7 a10.1111/1471-0307.131552DOI1 aBARBEITO, J.  aBovine milk as a source of nitro-conjugated linoleic acid.h[electronic resource]  c2024  aArticle history: Version of Record online 11 November 2024. -- Corresponding: Trostchansky, A.; Centro de Investigaciones Biomédicas (CEINBIO), Facultad de Medicina, Universidad de la República, Montevideo, Uruguay; email:trocha@fmed.edu.uy -- Funding: Agencia Nacional de Investigación e Innovación. Grant Number: FSA_1_2018_1_152220; Comisión Sectorial de Investigación Científica. Grant Number: Grupos 536; Programa de Desarrollo de las Ciencias Básicas. -- Publisher: John Wiley and Sons Inc.  aABSTRACT.- Nitrated fatty acids (NO2-FAs), specifically nitroalkenes, are gaining recognition for their anti-inflammatory and therapeutic properties. Bovine milk, a major dietary component, may serve as a significant source of these bioactive molecules, complementing its established nutritional profile. This study examined nitroalkene's presence in milk from different bovine strains and lactation stages. NO2-conjugated linoleic acid (NO2-cLA) was detected at concentrations up to 5 uM, comprising 2.7% of total cLA. The concentration of NO2-cLA varied slightly with the Holstein strain and lactation stage, with its free form predominantly observed, suggesting limited triglyceride incorporation. Further research into NO2-cLA's biological significance in milk is required. © 2024 Society of Dairy Technology.  aConjugated linoleic acid  aElectrophilic  aMass spectrometry  aMilk  aNitration  aNitro-conjugated linoleic acid  aSISTEMA LECHERO - INIA1 aMASTROGIOVANNI, M.1 aGARCÍA-ROCHE, M.1 aMENDOZA, A.1 aRUBBO, H.1 aCARRIQUIRY, M.1 aTROSTCHANSKY, A.  tInternational Journal of Dairy Technology, 2024. https://doi.org/10.1111/1471-0307.13155