02591naa a2200277 a 450000100080000000500110000800800410001902200140006002400270007410000140010124501490011526000090026450004720027352012510074565300130199665300220200965300210203165300560205265300270210865300120213570000160214770000140216370000170217770000160219477301030221010650162024-12-26       2024    bl uuuu     u00u1 u    #d  a0141-98387 a10.1111/pim.130792DOI1 aCOSTA, M.  aImpact of fasciola hepatica infection and triclabendazole treatment on humoral immune response in cattle. (Brief report).h[electronic resource]  c2024  aArticle history: Received 22 July 2024, Revised 11 November 2024, Accepted 22 November 2024, Record online 10 December 2024. -- Corresponding: Freire, T.; Laboratorio de Inmunomodulación y Vacunas, Unidad Académica de Inmunobiología, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay; email:tfreire@fmed.edu.uy -- Funding: Agencia Nacional de Investigación e Innovación, FCE:1_2021_166683. -- Publisher: John Wiley and Sons Inc. -- License:  aABSTRACT.- Fasciola hepatica is a trematode parasite of significant veterinary and public health importance, causing economic losses in livestock due to liver damage, weight loss and reduced milk production. Although triclabendazole (TCZ) is available for treatment, it does not prevent the disease or reinfection. Infected animals exhibit strong immunoregulation, increasing susceptibility to secondary infections and altering vaccine-induced antibody responses. This study investigates the humoral immune response in cattle infected with F. hepatica at different stages of infection and evaluates the effect of TCZ treatment on this response. It also examines how fasciolosis affects the antibody response induced by bacterial vaccines during early and chronic infection stages. Experimental infections in steers were conducted, with faecal and plasma samples collected at various intervals. The results showed a decrease in parasite-specific antibody avidity during infection. However, F. hepatica infection did not substantially modify antibody response to bacterial vaccines. This study underscores the need for further research on the impact of fasciolosis and its treatment on livestock vaccination efficacy. © 2024 John Wiley & Sons Ltd.  aAntibody  aFasciola hepatica  aImmunomodulation  aPLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA  aSISTEMA LECHERO - INIA  aVaccine1 aSARAVIA, A.1 aUBIOS, D.1 aPAOLAZZI, C.1 aCAPOZZO, A.  tParasite Immunology, December 2024, Volume 46, Issue 12, e13079. https://doi.org/10.1111/pim.13079