02317naa a2200385 a 450000100080000000500110000800800410001902200140006002400550007410000210012924501580015026000090030850004640031752006370078165300240141865300100144265300170145265300110146965300210148065300240150165300560152570000210158170000210160270000330162370000230165670000190167970000230169870000210172170000160174270000170175870000240177570000160179970000310181577300850184610652752025-07-07       2025    bl uuuu     u00u1 u    #d  a0041-01017 ahttps://doi.org/10.1016/j.toxicon.2025.1084082DOI1 aDE SOUSA, A.L.V.  aIntracerebral hemorrhage (hemorrhagic stroke) secondary to Bothrops spp. snakebite envenomation in a horse. [Short communication].h[electronic resource]  c2025  aArticle history: Received 24 April 2025; Received in revised form 9 May 2025; Accepted 11 May 2025: Available online 14 May 2025. -- Corresponding author: M.B. de Castro, Graduate, Program in Animal Science, University of Brasília, Brasilia, Brazil, e-mail: mbcastro@unb.br -- Funding: This study was partially funded by the Coordination for the Improvement of Higher Education Personnel (CAPES) - Brazil, Finance Code 001 (ALVS, DERS, ILM, LAC, and YNGF. --  aABSTRACT.- This report describes the first documented case of intracerebral hemorrhage (ICH) in a horse following Bothrops snakebite envenomation. A 3-year-old mare developed acute kidney injury, systemic hemorrhage, and neurological signs before euthanasia. Postmortem findings confirmed massive ICH with intralesional venom identified by immunohistochemistry. Delayed treatment and insufficient antivenom likely contributed to the outcome. This case highlights the potential for cerebrovascular complications following Bothrops snakebite envenomation in horses, which may present as subtle neurological signs. © 2025 Elsevier Ltd  aAcute kidney injury  aBrain  aCoagulopathy  aEquine  aINIA TACUAREMBÓ  aLancehead pit viper  aPLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA1 aDE SOUSA, D.E.R.1 aDE MACÊDO, I.L.1 aDE ALBUQUERQUE CERQUEIRA, L.1 aDA FONSECA, Y.N.G.1 aOLIVEIRA, A.B.1 aDAS CHAGAS, L.V.S.1 aGONÇALVES, G.B.1 aVEADO, H.C.1 aKELLER, K.M.1 aLOPES CÂMARA, A.C.1 aMACHADO, M.1 aDE CASTRO, MÁRCIO BOTELHO  tToxicon, 2025, volume 263, 108408. https://doi.org/10.1016/j.toxicon.2025.108408