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 | Acceso al texto completo restringido a Biblioteca INIA Las Brujas. Por información adicional contacte bibliolb@inia.org.uy. |
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha : |
26/12/2024 |
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Actualizado : |
26/12/2024 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
COSTA, M.; SARAVIA, A.; UBIOS, D.; PAOLAZZI, C.; CAPOZZO, A. |
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Afiliación : |
MONIQUE COSTA, Laboratorio de Inmunomodulación y Vacunas, Unidad Académica de Inmunobiología, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay; ANDERSON SARAVIA DE MELO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ORCID: https://orcid.org/0000-0002-3624-2437; DIEGO UBIOS, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; CLAUDIO PAOLAZZI, Agropharma Salud Animal S. A., Buenos Aires, Argentina; ALEJANDRA CAPOZZO, Centro de Altos Estudios en Ciencias Humanas y de la Salud, CONICET-Universidad Abierta Interamericana, Buenos Aires, Argentina. |
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Título : |
Impact of fasciola hepatica infection and triclabendazole treatment on humoral immune response in cattle. (Brief report). |
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Fecha de publicación : |
2024 |
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Fuente / Imprenta : |
Parasite Immunology, December 2024, Volume 46, Issue 12, e13079. https://doi.org/10.1111/pim.13079 |
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ISSN : |
0141-9838 |
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DOI : |
10.1111/pim.13079 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received 22 July 2024, Revised 11 November 2024, Accepted 22 November 2024, Record online 10 December 2024. -- Corresponding: Freire, T.; Laboratorio de Inmunomodulación y Vacunas, Unidad Académica de Inmunobiología, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay; email:tfreire@fmed.edu.uy -- Funding: Agencia Nacional de Investigación e Innovación, FCE:1_2021_166683. -- Publisher: John Wiley and Sons Inc. -- License: |
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Contenido : |
ABSTRACT.- Fasciola hepatica is a trematode parasite of significant veterinary and public health importance, causing economic losses in livestock due to liver damage, weight loss and reduced milk production. Although triclabendazole (TCZ) is available for treatment, it does not prevent the disease or reinfection. Infected animals exhibit strong immunoregulation, increasing susceptibility to secondary infections and altering vaccine-induced antibody responses. This study investigates the humoral immune response in cattle infected with F. hepatica at different stages of infection and evaluates the effect of TCZ treatment on this response. It also examines how fasciolosis affects the antibody response induced by bacterial vaccines during early and chronic infection stages. Experimental infections in steers were conducted, with faecal and plasma samples collected at various intervals. The results showed a decrease in parasite-specific antibody avidity during infection. However, F. hepatica infection did not substantially modify antibody response to bacterial vaccines. This study underscores the need for further research on the impact of fasciolosis and its treatment on livestock vaccination efficacy. © 2024 John Wiley & Sons Ltd. |
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Palabras claves : |
Antibody; Fasciola hepatica; Immunomodulation; PLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA; SISTEMA LECHERO - INIA; Vaccine. |
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Asunto categoría : |
L73 Enfermedades de los animales |
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Marc : |
LEADER 02591naa a2200277 a 4500
001 1065016
005 2024-12-26
008 2024 bl uuuu u00u1 u #d
022 $a0141-9838
024 7 $a10.1111/pim.13079$2DOI
100 1 $aCOSTA, M.
245 $aImpact of fasciola hepatica infection and triclabendazole treatment on humoral immune response in cattle. (Brief report).$h[electronic resource]
260 $c2024
500 $aArticle history: Received 22 July 2024, Revised 11 November 2024, Accepted 22 November 2024, Record online 10 December 2024. -- Corresponding: Freire, T.; Laboratorio de Inmunomodulación y Vacunas, Unidad Académica de Inmunobiología, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay; email:tfreire@fmed.edu.uy -- Funding: Agencia Nacional de Investigación e Innovación, FCE:1_2021_166683. -- Publisher: John Wiley and Sons Inc. -- License:
520 $aABSTRACT.- Fasciola hepatica is a trematode parasite of significant veterinary and public health importance, causing economic losses in livestock due to liver damage, weight loss and reduced milk production. Although triclabendazole (TCZ) is available for treatment, it does not prevent the disease or reinfection. Infected animals exhibit strong immunoregulation, increasing susceptibility to secondary infections and altering vaccine-induced antibody responses. This study investigates the humoral immune response in cattle infected with F. hepatica at different stages of infection and evaluates the effect of TCZ treatment on this response. It also examines how fasciolosis affects the antibody response induced by bacterial vaccines during early and chronic infection stages. Experimental infections in steers were conducted, with faecal and plasma samples collected at various intervals. The results showed a decrease in parasite-specific antibody avidity during infection. However, F. hepatica infection did not substantially modify antibody response to bacterial vaccines. This study underscores the need for further research on the impact of fasciolosis and its treatment on livestock vaccination efficacy. © 2024 John Wiley & Sons Ltd.
653 $aAntibody
653 $aFasciola hepatica
653 $aImmunomodulation
653 $aPLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA
653 $aSISTEMA LECHERO - INIA
653 $aVaccine
700 1 $aSARAVIA, A.
700 1 $aUBIOS, D.
700 1 $aPAOLAZZI, C.
700 1 $aCAPOZZO, A.
773 $tParasite Immunology, December 2024, Volume 46, Issue 12, e13079. https://doi.org/10.1111/pim.13079
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| 1. |  | Mederos, A.Casaretto, A.Ferreira, G.Bonino, J.Scremini, P. Evaluación de pérdidas productivas debidas a footrot en ovinos ln: Mederos, A.; Ferreira, G.; Montossi, F.; Bonino, J.; Casaretto, A.; Scremini, P.; Gil, A. Estudios sobre footrot ovino en el Uruguay: relevamiento de su prevalencia, evaluación de las pérdidas productivas y económicas. Tacuarembó (Uruguay): INIA, 2001. p. 9-15 (INIA Serie Actividades de Difusión ; 274)| Biblioteca(s): INIA La Estanzuela; INIA Las Brujas; INIA Tacuarembó. |
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| 3. | | MEDEROS, A.; CASARETTO, A.; FERREIRA, G.; BONINO, J.; SCREMINI, P.; LIMA, G.; GONZALEZ, H.; SILVA, L. Evaluación de pérdidas productivas debidas a footrot ln: INIA TACUAREMBÓ. UNIDAD EXPERIMENTAL "LA MAGNOLIA". Día de campo, Tacuarembó, 2000. Unidad Experimental La Magnolia. Tacuarembó (Uruguay): INIA, 2000. p. 17-24 (INIA Serie Actividades de Difusión ; 238) INIA Tacuarembó. Unidad Experimental La Magnolia| Biblioteca(s): INIA Tacuarembó. |
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